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Controlling Hypertension After Severe Cerebrovascular Event (CHASE): study protocol for a randomized controlled trial

Fang Yuan1, Fang Yang1, Changhu Xue2

  • 1Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.

Trials
|February 23, 2018
PubMed

Insights

This study investigates individualized blood pressure (BP) lowering for severe stroke patients. Results will guide optimal BP management in acute stroke care.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Clinical Trials

Background:

  • Optimal blood pressure (BP) targets for acute stroke remain undetermined.
  • No prior studies have specifically addressed BP management in severe stroke patients.

Purpose of the Study:

  • To investigate if individualized lowering of elevated BP improves outcomes in patients with acute severe stroke.
  • To establish optimal BP management strategies for severe stroke.

Main Methods:

  • The CHASE trial is a multicenter, randomized, controlled study involving 500 adult patients with acute severe stroke.
  • Participants were randomized to either individualized BP lowering (10-15% reduction) or guideline-recommended BP lowering.
  • Primary outcome: proportion of participants with a poor outcome (modified Rankin Scale ≥3) at 90 days.

Main Results:

  • Analysis of primary outcome using multivariate logistic regression adjusted for covariates.
  • Evaluation of secondary outcomes including disability at discharge and daily living activities at 90 days.

Conclusions:

  • The CHASE trial is the first to explore optimum BP management for acute severe stroke.
  • Findings may provide evidence for individualized BP lowering targets in severe stroke patients.
Abstract

Keywords:
Blood pressureCritical careHypertensionPrognosisSevere stroke

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