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Controlling Hypertension After Severe Cerebrovascular Event (CHASE): study protocol for a randomized controlled trial
Fang Yuan1, Fang Yang1, Changhu Xue2
1Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Trials
|February 23, 2018
Summary
This study investigates individualized blood pressure (BP) lowering for severe stroke patients. Results will guide optimal BP management in acute stroke care.
Area of Science:
- Neurology
- Cardiovascular Medicine
- Clinical Trials
Background:
- Optimal blood pressure (BP) targets for acute stroke remain undetermined.
- No prior studies have specifically addressed BP management in severe stroke patients.
Purpose of the Study:
- To investigate if individualized lowering of elevated BP improves outcomes in patients with acute severe stroke.
- To establish optimal BP management strategies for severe stroke.
Main Methods:
- The CHASE trial is a multicenter, randomized, controlled study involving 500 adult patients with acute severe stroke.
- Participants were randomized to either individualized BP lowering (10-15% reduction) or guideline-recommended BP lowering.
- Primary outcome: proportion of participants with a poor outcome (modified Rankin Scale ≥3) at 90 days.
Main Results:
- Analysis of primary outcome using multivariate logistic regression adjusted for covariates.
- Evaluation of secondary outcomes including disability at discharge and daily living activities at 90 days.
Conclusions:
- The CHASE trial is the first to explore optimum BP management for acute severe stroke.
- Findings may provide evidence for individualized BP lowering targets in severe stroke patients.
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