Related Experiment Video

Updated: Feb 14, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

84.6K

Predictive effect of hyperuricemia on left atrial stasis in non-valvular atrial fibrillation patients

Fang-Zhou Liu1, Hong-Tao Liao1, Wei-Dong Lin1

  • 1Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, China.

International Journal of Cardiology
|February 23, 2018
PubMed

Insights

High uric acid levels (hyperuricemia) are linked to left atrial thrombus/spontaneous echo contrast in non-valvular atrial fibrillation patients. Hyperuricemia may independently predict this risk, especially in those with lower CHA2DS2-VASc scores.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Biochemistry

Background:

  • Non-valvular atrial fibrillation (NVAF) poses a significant stroke risk.
  • Left atrial thrombus (LAT) and spontaneous echo contrast (SEC) are indicators of LA stasis and increased embolic risk in NVAF patients.
  • The role of hyperuricemia in predicting LA stasis in NVAF remains to be fully elucidated.

Purpose of the Study:

  • To investigate the association between serum uric acid (SUA) levels, hyperuricemia, and the presence of LAT/SEC in NVAF patients.
  • To determine if hyperuricemia serves as an independent predictor of LAT/SEC in this population.
  • To explore the potential of combining hyperuricemia assessment with CHA2DS2-VASc scores for refined risk stratification.

Main Methods:

  • Retrospective analysis of 1198 NVAF patients undergoing transesophageal echocardiography (TEE).
  • Patients were categorized based on TEE findings into LAT/SEC and normal groups.
  • Clinical data, including SUA levels and comorbidities, were collected and analyzed, with logistic regression used for predictor identification.

Main Results:

  • A significant proportion of patients (8.1%) exhibited LAT or SEC.
  • Patients with LAT/SEC demonstrated markedly higher mean SUA levels and hyperuricemia prevalence.
  • Both SUA level (OR=1.004) and hyperuricemia (OR=1.69) were identified as independent predictors of LAT/SEC after multivariable adjustment.

Conclusions:

  • Serum uric acid levels and hyperuricemia are closely associated with left atrial stasis in NVAF patients.
  • Hyperuricemia independently predicts LA stasis and may help refine risk stratification, particularly in patients with a CHA2DS2-VASc score below 2.
Abstract

Keywords:
Atrial fibrillationHyperuricemiaLeft atrial thrombusSpontaneous echo contrastThromboembolic event

More Related Videos

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

34.2K
Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

2.2K

Related Concept Videos

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias

Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
611
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
12.1K
Amyloid Fibrils03:03

Amyloid Fibrils

6.5K
Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
3.4K
Predicting Molecular Geometry02:27

Predicting Molecular Geometry

VSEPR Theory for Determination of Electron Pair Geometries
46.1K
Prediction Intervals01:03

Prediction Intervals

The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y. 
3.4K