Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Plasmids01:28

Plasmids

2.9K
Plasmids are extrachromosomal DNA molecules found in bacteria, archaea, and some eukaryotic microbes like yeast. These small, circular DNA structures typically contain fewer than 30 genes, although some may exist linearly. Plasmids vary in their number within a cell, known as copy number. Single-copy plasmids are present in one copy per cell and multi-copy plasmids are present in multiple copies, reaching over 100 copies per cell.Plasmids usually replicate independently of the chromosomal DNA...
2.9K
What are Viruses?00:50

What are Viruses?

128.4K
Overview
128.4K
Extraction: Partition and Distribution Coefficients01:14

Extraction: Partition and Distribution Coefficients

5.0K
The distribution law or Nernst's distribution law is the law that governs the distribution of a solute between two immiscible solvents. This law, also known as the partition law, states that if a solute is added to the mixture of two immiscible solvents at a constant temperature, the solute is distributed between the two solvents in such a way that the ratio of solute concentrations in the solvents remains constant at equilibrium.
For extracting a solute from an aqueous phase into an...
5.0K
Introduction to Virus01:28

Introduction to Virus

1.8K
Viruses are unique biological entities that blur the boundary between living and non-living systems. Although they lack cellular structure and metabolic processes, they can exhibit characteristics of life when infecting a host. Their defining feature is a nucleic acid core, composed of either DNA or RNA, encapsulated within a protein coat called a capsid. This simple structure allows them to invade host cells and use their machinery for replication efficiently.Viral Structure and...
1.8K
Viruses of Archaea01:29

Viruses of Archaea

532
Archaeal viruses play a crucial role in the ecosystems of extremophilic archaea, particularly those belonging to the phyla Euryarchaeota and Crenarchaeota. By shaping host evolution and facilitating gene transfer, these viruses influence microbial communities and contribute to genetic diversity in extreme environments. The archaea they infect thrive in acidic hot springs and hydrothermal vents characterized by high temperatures and low pH. Archaeal viruses exhibit remarkable structural...
532
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

959
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
959

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of deubiquitination of Epstein-Barr virus Rta and Zta on lytic development.

Microbiology spectrum·2026
Same author

PhenoAge acceleration predicts antibody persistence and breakthrough infection after SARS-CoV-2 vaccination and infection.

Journal of infection and public health·2025
Same author

Enhancement of respiratory virus infection by air pollutants.

Ecotoxicology and environmental safety·2025
Same author

Kaposi sarcoma-associated herpesvirus cooperates with Epstein-Barr virus to co-transform a small set of human B cells oncogenically.

PLoS pathogens·2025
Same author

Assessing the fitness of Epstein-Barr virus following its reactivation.

Journal of virology·2025
Same author

Response to: Association between Epstein-Barr virus infection and gastric cancer.

QJM : monthly journal of the Association of Physicians·2025

Related Experiment Video

Updated: Feb 14, 2026

Generation of Recombinant Influenza Virus from Plasmid DNA
11:31

Generation of Recombinant Influenza Virus from Plasmid DNA

Published on: August 3, 2010

32.2K

Plasmid Partitioning by Human Tumor Viruses.

Ya-Fang Chiu1,2,3, Bill Sugden4

  • 1Department of Microbiology and Immunology, Chang-Gung University, Taoyuan, Taiwan.

Journal of Virology
|February 23, 2018
PubMed
Summary

Human tumor viruses replicate as plasmids and share DNA synthesis features. These viruses may partition to daughter cells before mitosis, unlike host chromosomes.

Keywords:
human tumor virusespartitioningsynthesis

More Related Videos

Author Spotlight: Modeling Brain Tumors In Vivo Using Electroporation-Based Delivery of Plasmid DNA Representing Patient Mutation Signatures
04:01

Author Spotlight: Modeling Brain Tumors In Vivo Using Electroporation-Based Delivery of Plasmid DNA Representing Patient Mutation Signatures

Published on: June 23, 2023

3.0K
Rescue and Characterization of Recombinant Virus from a New World Zika Virus Infectious Clone
07:35

Rescue and Characterization of Recombinant Virus from a New World Zika Virus Infectious Clone

Published on: June 7, 2017

10.2K

Related Experiment Videos

Last Updated: Feb 14, 2026

Generation of Recombinant Influenza Virus from Plasmid DNA
11:31

Generation of Recombinant Influenza Virus from Plasmid DNA

Published on: August 3, 2010

32.2K
Author Spotlight: Modeling Brain Tumors In Vivo Using Electroporation-Based Delivery of Plasmid DNA Representing Patient Mutation Signatures
04:01

Author Spotlight: Modeling Brain Tumors In Vivo Using Electroporation-Based Delivery of Plasmid DNA Representing Patient Mutation Signatures

Published on: June 23, 2023

3.0K
Rescue and Characterization of Recombinant Virus from a New World Zika Virus Infectious Clone
07:35

Rescue and Characterization of Recombinant Virus from a New World Zika Virus Infectious Clone

Published on: June 7, 2017

10.2K

Area of Science:

  • * Molecular Biology
  • * Virology
  • * Cell Biology

Background:

  • * Human tumor viruses, such as those replicating as plasmids, exhibit unique DNA replication strategies.
  • * The term 'plasmid' is used to distinguish these extrachromosomal DNA elements from 'episomes,' which can integrate into the host genome.
  • * Understanding viral DNA maintenance in proliferating cells is crucial for comprehending their propagation.

Purpose of the Study:

  • * To explore the DNA synthesis mechanisms common to human tumor viruses that replicate as plasmids.
  • * To investigate the less understood mechanisms of viral DNA maintenance and partitioning in proliferating host cells.
  • * To highlight the distinct timing of viral DNA partitioning compared to host chromosome segregation.

Main Methods:

  • * Comparative analysis of DNA synthesis pathways in human tumor viruses replicating as plasmids.
  • * Examination of cellular mechanisms governing the maintenance and segregation of viral DNA during cell proliferation.
  • * Theoretical modeling of viral DNA partitioning in relation to the host cell cycle.

Main Results:

  • * Human tumor viruses replicating as plasmids share conserved DNA synthesis features.
  • * Viral DNA maintenance mechanisms are critical for ensuring partitioning to daughter cells.
  • * These viruses appear to initiate partitioning in the S phase, preceding mitosis.

Conclusions:

  • * Human tumor viruses possess distinct DNA replication and maintenance strategies.
  • * Viral DNA partitioning occurs earlier in the cell cycle than host chromosome partitioning.
  • * Further research into these mechanisms could reveal novel therapeutic targets.