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A human bone marrow mesodermal-derived cell population with hemogenic potential.

Saloomeh Mokhtari1, Evan Colletti2, Weihong Yin1

  • 1Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, 27157, USA.

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Researchers identified a novel human cell population in bone marrow with both endothelial and blood-forming potential. These cells can be expanded and differentiated, offering new therapeutic targets for blood disorders.

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Area of Science:

  • Hematology
  • Developmental Biology
  • Cell Biology

Background:

  • The existence of cells with dual endothelial and hemogenic potential in human bone marrow has been debated.
  • Understanding the origins of hematopoiesis and vascular development is crucial for regenerative medicine.

Purpose of the Study:

  • To identify and characterize a specific cell population in human bone marrow exhibiting both endothelial and hemogenic potential.
  • To investigate the in vitro and in vivo behavior of these cells for potential therapeutic applications.

Main Methods:

  • Isolation and characterization of APLNR+, Stro-1+ cells from human fetal and adult bone marrow.
  • In vitro culture expansion and differentiation induction using OCT4.
  • In vivo transplantation studies in a fetal microenvironment.

Main Results:

  • Identification of a unique APLNR+, Stro-1+ cell population in fetal bone marrow with mesodermal and hemogenic endothelium markers.
  • Adult bone marrow contains these cells at low frequency; they can be expanded in vitro, retaining a hemogenic transcriptional profile.
  • In vitro OCT4 induction drives these cells to a hematopoietic phenotype.
  • In vivo, transplanted cells contribute to vasculature and generate multilineage hematopoietic cells.

Conclusions:

  • The discovery of this human somatic cell population offers new insights into ontogenetic hematovascular potential.
  • These findings could pave the way for novel therapeutic strategies for hematologic disorders.