Related Experiment Video

Updated: Feb 14, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
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An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

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Targeting MYC in multiple myeloma

K K Jovanović1, C Roche-Lestienne1,2, I M Ghobrial3

  • 1IRCL, INSERM UMR-S1172, Univ. Lille, Lille, France.

Leukemia
|February 23, 2018
PubMed

Insights

Multiple myeloma involves MYC gene activation, a key driver of cancer progression. Targeting MYC offers precision medicine strategies for treating this plasma cell tumor.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Multiple myeloma (MM) is a plasma cell malignancy characterized by clonal evolution.
  • MYC activation, often via genetic alterations, is a critical step in MM progression.
  • Understanding MYC deregulation is crucial for developing targeted therapies.

Purpose of the Study:

  • To review the mechanisms of MYC activation in multiple myeloma.
  • To elucidate the role of MYC in MM pathogenesis and cancer progression.
  • To discuss current and emerging therapeutic strategies targeting MYC in MM.

Main Methods:

  • Literature review of molecular mechanisms and genetic alterations.
  • Analysis of pathways regulating MYC expression (e.g., IRF4, MAPK).
  • Examination of preclinical and clinical data on MYC-targeted therapies.

Main Results:

  • MYC activation in MM results from genetic events like translocations or locus gain.
  • Deregulation involves upstream pathways including IRF4 and DIS3/LIN28B/let-7.
  • MYC plays a significant role in the clonal evolution and progression of MM.
  • Targeting MYC directly or indirectly presents therapeutic vulnerabilities.

Conclusions:

  • MYC activation is a pivotal event in multiple myeloma development and progression.
  • Targeting MYC offers a promising avenue for precision medicine in MM.
  • Further clinical evaluation of MYC-directed therapies is warranted for MM patients.

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