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Updated: Feb 14, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Eye Movement Abnormalities in Multiple Sclerosis: Pathogenesis, Modeling, and Treatment.

Alessandro Serra¹, Clara G Chisari², Manuela Matta³

¹Neurology, Louis Stokes VA Medical Center, University Hospitals and Case Western Reserve School of Medicine, Cleveland, OH, United States.

Frontiers in Neurology

|February 23, 2018

Summary

Multiple sclerosis (MS) causes eye movement disorders like acquired pendular nystagmus (APN) and internuclear ophthalmoplegia (INO). Studying these can reveal MS mechanisms and aid in developing new treatments.

Keywords:

eye movements internuclear ophthalmoplegia multiple sclerosis nystagmus pathologic saccades

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A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS

Published on: December 26, 2015

Area of Science:

Neuroscience
Ophthalmology
Neurology

Background:

Multiple sclerosis (MS) frequently leads to ocular motor abnormalities, significantly impacting patient disability.
Lesions in the posterior fossa are common causes of disorders such as acquired pendular nystagmus (APN) and internuclear ophthalmoplegia (INO).

Purpose of the Study:

To explore how studying ocular motor abnormalities in MS can provide insights into disease mechanisms.
To investigate the potential of quantitative measurement and modeling of eye movement disorders for understanding MS symptoms like Uhthoff's phenomenon and fatigue.

Main Methods:

Correlation of experimental models with neuroimaging-identified lesion localization in MS to clarify pathophysiology.
Quantitative measurement and computational modeling of specific eye movement disorders, such as INO.

Main Results:

The study clarifies the pathophysiology of APN by correlating experimental models with lesion localization in MS patients.
Quantitative analysis of INO may enhance understanding of MS-related fatigue and Uhthoff's phenomenon.

Conclusions:

Eye movement disorders in MS can serve as biomarkers for early cognitive deficits and disease progression.
Ocular motor abnormalities offer a platform for testing novel therapeutic agents for MS.
Neuropharmacology of eye movement dysfunction guides treatment strategies for APN and central nystagmus in MS.