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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Thermodynamics of a Redox Reaction
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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Potential of Stem Cell-Based Therapy for Ischemic Stroke.

Hany E Marei1, A Hasan2, R Rizzi3

  • 1Biomedical Research Center, Qatar University, Doha, Qatar.

Frontiers in Neurology
|February 23, 2018
PubMed
Summary

Stem cell therapy shows promise for ischemic stroke, but results vary. More research is needed to understand mechanisms and optimize treatment timing for stroke recovery.

Keywords:
induced pluripotent stem cellsischemic strokemesenchymal stem cellneural stem cellstem cell

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Biomedical Engineering

Background:

  • Ischemic stroke is a leading global health concern.
  • Tissue plasminogen activator is the sole FDA-approved drug for acute ischemic stroke.
  • Stem cell therapy is being investigated as a potential stroke treatment.

Purpose of the Study:

  • To review preclinical and clinical studies on stem cell therapy for ischemic stroke.
  • To explore the therapeutic potential and outcomes of various stem cell types.
  • To identify knowledge gaps regarding stem cell mechanisms and treatment windows.

Main Methods:

  • Systematic review of existing literature on stem cell stroke therapy.
  • Analysis of preclinical and clinical trial data.
  • Evaluation of different stem cell types including neural stem cells (NSCs) and mesenchymal stem cells.

Main Results:

  • Stem cell therapy presents intriguing but often conflicting results for ischemic stroke.
  • The mechanisms of action for engrafted stem/progenitor cells remain largely unknown.
  • Current clinical trials often utilize limited or short time windows for intervention.

Conclusions:

  • Stem cell-based therapies offer potential for treating ischemic stroke.
  • Further clinical trials are required to assess long-term efficacy and optimal timing.
  • Understanding the mechanisms of stem cell action is crucial for therapeutic development.