Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

9.3K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.3K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.7K
3.7K
What are Viruses?00:50

What are Viruses?

128.4K
Overview
128.4K
Mitochondrial Protein Sorting01:39

Mitochondrial Protein Sorting

5.8K
Mitochondria are double-membrane organelles of the eukaryotes involved in cellular metabolism, signaling, ATP synthesis, and programmed cell death.  Each of these processes requires specific proteins and enzymes that must be correctly sorted to the right mitochondrial subcompartment for the proper functioning of the organelle.
Most of these mitochondrial proteins are encoded by the nucleus and imported to the mitochondria as unfolded or loosely folded precursors. Mitochondrial precursors...
5.8K
Mitochondrial Precursor Proteins01:39

Mitochondrial Precursor Proteins

3.8K
Mitochondrial precursors are partially unfolded or loosely folded polypeptide chains. Newly synthesized precursors are inhibited from spontaneously folding into their native conformation by the cytosolic chaperones, heat shock proteins 70 (Hsp70), and mitochondrial import stimulation factors (MSFs). Precursors bound to MSFs are guided to the TOM70-TOM37 receptors, while precursors bound to Hsp70  chaperones are targetted to TOM20-TOM22 receptor complexes.
Most of the mitochondrial...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Current and Emerging Roles of GLP1 Receptor Agonists Across the Spectrum of Left Ventricular Ejection Fraction in Heart Failure.

Biomolecules·2025
Same author

Circulating microRNAs as biomarkers for risk assessment and prognostic stratification of pleural mesothelioma.

Lung cancer (Amsterdam, Netherlands)·2025
Same author

mTOR inhibition sensitizes T-ALL cells to Venetoclax through engagement of the integrated stress response.

Signal transduction and targeted therapy·2025
Same author

HTLV-1 p13 Protein Hijacks Macrophage Polarization and Promotes T-Cell Recruitment.

Viruses·2025
Same author

Beyond Telomeres: Unveiling the Extratelomeric Functions of TERT in B-Cell Malignancies.

Cancers·2025
Same author

The Role of SGLT2-Inhibitors Across All Stages of Heart Failure and Mechanisms of Early Clinical Benefit: From Prevention to Advanced Heart Failure.

Biomedicines·2025

Related Experiment Video

Updated: Feb 14, 2026

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood
09:40

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood

Published on: November 28, 2018

7.8K

Mitochondrial Proteins Coded by Human Tumor Viruses.

Ilaria Cavallari1, Gloria Scattolin2, Micol Silic-Benussi1

  • 1Veneto Institute of Oncology IOV-IRRCS, Padova, Italy.

Frontiers in Microbiology
|February 23, 2018
PubMed
Summary

Human tumor viruses interact with mitochondria, crucial cell components involved in energy, immunity, and cell death. These interactions aid viral replication and disease development.

Keywords:
EBVHBVHCVHPVHTLV-1KSHVMitochondria

More Related Videos

Detecting Virus and Salivary Proteins of a Leafhopper Vector in the Plant Host
07:23

Detecting Virus and Salivary Proteins of a Leafhopper Vector in the Plant Host

Published on: September 14, 2021

2.8K
Analytical Determination of Mitochondrial Function of Excised Solid Tumor Homogenates
11:32

Analytical Determination of Mitochondrial Function of Excised Solid Tumor Homogenates

Published on: August 6, 2021

3.1K

Related Experiment Videos

Last Updated: Feb 14, 2026

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood
09:40

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood

Published on: November 28, 2018

7.8K
Detecting Virus and Salivary Proteins of a Leafhopper Vector in the Plant Host
07:23

Detecting Virus and Salivary Proteins of a Leafhopper Vector in the Plant Host

Published on: September 14, 2021

2.8K
Analytical Determination of Mitochondrial Function of Excised Solid Tumor Homogenates
11:32

Analytical Determination of Mitochondrial Function of Excised Solid Tumor Homogenates

Published on: August 6, 2021

3.1K

Area of Science:

  • Virology
  • Cell Biology
  • Mitochondrial Biology

Background:

  • Mitochondria are vital for cellular energy production, apoptosis, immunity, and redox balance.
  • Viruses, particularly tumor viruses, target mitochondria to hijack cellular processes for replication.
  • Understanding virus-mitochondria interactions is key to comprehending viral pathogenesis.

Purpose of the Study:

  • To review the interactions between mitochondria and proteins encoded by human tumor viruses.
  • To elucidate how these interactions facilitate viral replication, persistence, and cellular transformation.
  • To highlight the significance of mitochondria as functional targets for oncogenic viruses.

Main Methods:

  • Literature review of scientific publications on human tumor viruses and mitochondria.
  • Analysis of studies detailing viral protein interactions with mitochondrial functions.
  • Synthesis of information on the roles of mitochondria in viral life cycles.

Main Results:

  • Human T-cell leukemia virus type 1, Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus, hepatitis B virus, hepatitis C virus, and human papillomavirus proteins interact with mitochondria.
  • These interactions modulate mitochondrial bioenergetics, apoptosis, and innate immunity.
  • Mitochondrial manipulation by these viruses supports viral replication, persistence, and oncogenesis.

Conclusions:

  • Mitochondria are critical targets for human tumor viruses, influencing viral lifecycle and disease.
  • Virus-induced alterations in mitochondrial function are central to viral persistence and transformation.
  • Targeting virus-mitochondria interactions may offer therapeutic strategies against viral-associated cancers.