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The Macrophage Mannose Receptor Regulate Mannan-Induced Psoriasis, Psoriatic Arthritis, and Rheumatoid Arthritis-Like

Cecilia Hagert1,2, Outi Sareila1,3, Tiina Kelkka1,4

  • 1Medicity Research Laboratory, University of Turku, Turku, Finland.

Frontiers in Immunology
|February 23, 2018
PubMed

Insights

Mannose receptor (MR) deficiency exacerbates mannan-induced inflammatory diseases like psoriasis and arthritis in mice. MR protects against severe disease by regulating macrophage responses and reactive oxygen species (ROS) production.

Area of Science:

  • Immunology
  • Inflammation Research
  • Macrophage Biology

Background:

  • Mannan injection in mice induces psoriasis (Ps) and psoriatic arthritis (PsA).
  • Neutrophil cytosolic factor 1 (Ncf1) deficiency worsens these conditions by impairing reactive oxygen species (ROS) burst in macrophages.
  • The macrophage mannose receptor (MR, CD206) binds mannan and is investigated for its role in these inflammatory diseases.

Purpose of the Study:

  • To investigate the role of the macrophage mannose receptor (MR, CD206) in mannan-induced inflammatory conditions.
  • To determine how MR deficiency affects the severity of psoriasis, psoriatic arthritis, and rheumatoid-like arthritis.
  • To explore the interplay between MR, Ncf1, and macrophage activation in disease pathogenesis.

Main Methods:

  • Utilized mouse models deficient in MR expression.
  • Induced inflammatory conditions using mannan injection, with and without antibodies to collagen type II.
  • Analyzed disease severity and characterized macrophage populations, including Ncf1 status and ROS production.

Main Results:

  • Mice deficient in MR exhibited more severe mannan-induced Ps, PsA, and rheumatoid-like arthritis.
  • MR-mediated protection was diminished in Ncf1-mutated mice.
  • The protective effect of MR was associated with a type 2 macrophage expansion and ROS induction.

Conclusions:

  • Macrophage mannose receptor (MR) plays a protective role against pathogenic inflammatory responses induced by mannan.
  • MR signaling is crucial for regulating macrophage activation and ROS production in inflammatory arthritis and psoriasis.
  • Targeting MR may offer therapeutic potential for inflammatory diseases driven by mannan-mediated pathways.
Keywords:
macrophage mannose receptor (CD206)mannanpsoriasispsoriatic arthritisreactive oxygen speciesrheumatoid arthritis

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