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Sibling Ethambutol Optic Chiasmopathy.

Viran Jayanetti1, Michael Rossiter-Thornton1, Domit Azar1

  • 1Concord Repatriation General Hospital, Concord, New South Wales, Australia.

Neuro-Ophthalmology (Aeolus Press)
|February 23, 2018
PubMed
Summary
This summary is machine-generated.

Ethambutol can cause optic chiasmopathy, a vision condition. Researchers suggest genetic factors may increase risk and explore potential treatments like vitamin B for this ethambutol side effect.

Keywords:
EthambutolLeber’s hereditary optic neuropathymitochondriaoptic chiasmopathyoptic neuropathy

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Area of Science:

  • Ophthalmology
  • Neurology
  • Genetics

Background:

  • Ethambutol is a key treatment for Mycobacterium avium and Mycobacterium tuberculosis.
  • Optic neuropathies, including ethambutol optic neuropathy (EON), can impair vision.
  • Mitochondrial optic neuropathies share pathophysiological similarities.

Observation:

  • Two siblings presented with ethambutol-induced optic chiasmopathy.
  • Vision improved in both siblings after discontinuing ethambutol.

Findings:

  • The study suggests a potential genetic predisposition to developing ethambutol optic neuropathy.
  • Shared pathophysiology between EON and Leber's hereditary optic neuropathy (LHON) is highlighted.

Implications:

  • Vitamin B supplementation and idebenone, used for LHON, may be potential treatments for EON.
  • Further research into genetic susceptibility and therapeutic strategies for EON is warranted.