Related Experiment Video

Updated: Feb 14, 2026

Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer
07:13

Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer

Published on: March 26, 2014

24.0K

Discoidin domain receptor 1: New star in cancer-targeted therapy and its complex role in breast carcinoma

Hui Jing1, Jingyuan Song1,2, Junnian Zheng1,2,3

  • 1Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China.

Oncology Letters
|February 23, 2018
PubMed

Insights

Discoidin domain receptor 1 (DDR1) has complex roles in breast cancer, sometimes inhibiting tumor growth but often promoting survival and invasion. Understanding DDR1 is key for developing new breast carcinoma therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase.
  • DDR1 influences cell attachment, migration, survival, and proliferation.
  • Its role in breast carcinoma is complex and not fully understood.

Purpose of the Study:

  • To review the multifaceted roles of DDR1 in breast carcinoma.
  • To explore the contradictory functions of DDR1 in tumor progression.
  • To identify DDR1 as a potential therapeutic target in breast cancer.

Main Methods:

  • Literature review of studies on DDR1 in breast carcinoma.
  • Analysis of experimental and clinical data.
  • Synthesis of current knowledge on DDR1's functions.

Main Results:

  • DDR1 exhibits dual roles in breast carcinoma, with conflicting reports on its effects.
  • Some studies indicate DDR1 promotes apoptosis and inhibits migration.
  • Other research links DDR1 to tumor cell survival, chemoresistance, and invasion.

Conclusions:

  • The precise role of DDR1 in breast carcinoma remains complex and context-dependent.
  • DDR1's involvement in tumor cell survival and invasion highlights its therapeutic potential.
  • Targeting DDR1 may offer a novel strategy for breast cancer treatment.
Keywords:
breast carcinomacollagendiscoidin domain receptor 1epithelial-mesenchymal transitionmigration

More Related Videos

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis07:47

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis

Published on: June 26, 2016

10.2K
Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

20.7K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
14.7K
Internal Receptors01:31

Internal Receptors

Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.7K
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
649
Three Developmental Domains01:29

Three Developmental Domains

Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and weight,...
1.2K