Related Experiment Video

Updated: Feb 14, 2026

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
08:52

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids

Published on: November 22, 2021

4.7K

Apatinib as a third- or further- line treatment in patients with advanced NSCLC harboring wild-type EGFR

Shencun Fang1, Meiling Zhang2, Guihong Wei3

  • 1Department of Respiratory Medicine Center, Nanjing Chest Hospital, Nanjing, Jiangsu, China.

Oncotarget
|February 23, 2018
PubMed
Abstract

Insights

Apatinib shows efficacy in advanced non-small cell lung cancer (NSCLC) patients with EGFR wild-type, offering a valuable third-line therapy option. This treatment demonstrated a 75% disease control rate with manageable side effects.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Advanced non-small cell lung cancer (NSCLC) with EGFR wild-type often presents treatment challenges after multiple chemotherapy lines.
  • Identifying effective salvage therapies is crucial for improving patient outcomes in this refractory population.

Purpose of the Study:

  • To evaluate the efficacy and safety of apatinib as a third- or further-line treatment for advanced NSCLC patients with EGFR wild-type.
  • To determine prognostic factors influencing survival in this patient cohort.

Main Methods:

  • Retrospective analysis of 36 EGFR wild-type advanced NSCLC patients treated with apatinib (January 2014 - August 2016).
  • Evaluation of objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and adverse events (AEs).
  • Univariate and multivariate analyses to identify prognostic variables.

Main Results:

  • The objective response rate (ORR) was 16.7% and the disease control rate (DCR) was 75%.
  • Median progression-free survival (PFS) was 4.5 months, and median overall survival (OS) was 8.2 months.
  • Good performance status was a significant prognostic factor for longer OS (p = 0.015); most adverse events were mild to moderate.

Conclusions:

  • Apatinib demonstrates promising efficacy and tolerable toxicity in advanced NSCLC patients with EGFR wild-type who have failed multiple prior therapies.
  • Apatinib is recommended as a third- or further-line treatment option for this patient population.
  • Further prospective studies may validate these findings and optimize treatment strategies.
Keywords:
VEGFR-2angiogenesisapatinibnon-small-cell lung cancer

More Related Videos

Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool08:49

Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool

Published on: May 27, 2016

11.7K
Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation15:05

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Published on: May 20, 2020

9.3K

Related Concept Videos

Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups


Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
30.4K
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.2K
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
73.0K
Types of Hormones02:13

Types of Hormones

Hormones can be classified into three main types based on their chemical structures: steroids, peptides, and amines. Their actions are mediated by the specific receptors they bind to on target cells.
84.4K
Sample Preparation for Analysis: Advanced Techniques01:08

Sample Preparation for Analysis: Advanced Techniques

Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
1.5K
Types of Selection01:46

Types of Selection

Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
45.3K