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Updated: Feb 14, 2026

Measuring Left Ventricular Pressure in Late Embryonic and Neonatal Mice
Published on: February 23, 2012
Late-onset bleb-associated endophthalmitis and continuous positive airway pressure
Erich J Berg1, John B Davies2, Mark R Buboltz1
1Clinical Research Department, Minnesota Eye Consultants, P.A. 9801 Dupont Avenue S. #200, Bloomington, MN 55431, USA.
Purpose:
To raise awareness of a possible association between continuous positive airway pressure (CPAP) devices and postoperative bleb-related infection.
Observations:
A 57-year old patient on CPAP presented with unilateral bleb-associated endophthalmitis 32 months after routine ExPress Trabeculectomy with mitomycin C. The offending organism, Streptococcus mitis, is a nonmotile and generally non-virulent pathogen which predominates in the normal human respiratory flora.
Conclusions And Importance:
This conceptual report underscores a potential relationship between CPAP use and bleb-associated endophthalmitis. Streptococcal species are the most commonly reported causative organisms in bleb-associated endophthalmitis, and S. mitis is of particular concern as the most abundant microbe among all human oral flora. A logical risk factor for infection, the CPAP device may inadvertently deliver such organisms to the vulnerable conjunctival filtering bleb.
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