Related Experiment Video
Updated: Feb 14, 2026
12:45
Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
Published on: February 12, 2022
6.7K
Additional lymph node dissection for primary colorectal cancer invading another colon region.
Ryuma Tokunaga1, Yasuo Sakamoto1, Shigeki Nakagawa1
1Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan.
Surgery Today
|February 23, 2018
Summary
For colorectal cancer (CRC) invading another colon region, additional regional lymph node dissection may be crucial. This surgery can help prevent lymph node recurrences, improving patient outcomes.
Area of Science:
- Oncology
- Surgical Oncology
- Gastroenterology
Background:
- Colorectal cancer (CRC) is a significant health concern, with surgery being the primary curative treatment.
- The management of CRC with regional invasion presents unique challenges in ensuring complete tumor removal and preventing recurrence.
Purpose of the Study:
- To evaluate the utility of additional regional lymph node dissection in primary colorectal cancer (CRC) that has invaded another region of the colon.
- To determine if this surgical approach impacts recurrence rates and patient outcomes.
Main Methods:
- A retrospective review of eight patients with CRC invading another colon region who underwent surgery between March 2005 and August 2014.
- Analysis of clinicopathological characteristics and patient outcomes, focusing on regional lymph node status and recurrence patterns.
Main Results:
- One of five patients who received additional regional lymph node dissection had lymph node metastasis.
- Two of three patients who did not undergo additional dissection experienced regional lymph node recurrences.
- While no statistical correlation was found with extra-regional metastasis, patients with such metastasis or recurrence had primary regional lymph node metastasis.
Conclusions:
- Additional regional lymph node dissection may be a necessary component of curative-intent surgery for primary colorectal cancer (CRC) with regional invasion.
- This procedure could potentially reduce the risk of regional lymph node recurrence in specific CRC cases.
Related Concept Videos
01:23Detailed Structure and Function of Lymph Nodes
5.1K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
5.1K
02:22The Colonization of Land
37.8K
Changes in the environment of the early Earth drove the evolution of organisms. As prokaryotic organisms in the oceans began to photosynthesize, they produced oxygen. Eventually, oxygen saturated the oceans and entered the air, resulting in an increase in atmospheric oxygen concentration, known as the oxygen revolution approximately 2.3 billion years ago. Therefore, organisms that could use oxygen for cellular respiration had an advantage. More than 1.5 years ago, eukaryotic cells and...
37.8K
01:27Conjugate Addition (1,4-Addition) vs Direct Addition (1,2-Addition)
4.4K
α,β-Unsaturated carbonyl compounds with two electrophilic sites, the carbonyl carbon, and the β carbon, are susceptible to nucleophilic attack via two modes: conjugate or 1,4-addition and direct or 1,2-addition.
Conjugate addition results in a thermodynamically stable product. The reaction retains the stronger C=O bond at the expense of the weaker C=C π bond. The process is slow as the β carbon is less electrophilic than the carbonyl carbon.
Direct addition products are...
Conjugate addition results in a thermodynamically stable product. The reaction retains the stronger C=O bond at the expense of the weaker C=C π bond. The process is slow as the β carbon is less electrophilic than the carbonyl carbon.
Direct addition products are...
4.4K
02:10Additional Subnuclear Structures
5.4K
The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals.
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles,...
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles,...
5.4K
02:10Additional Subnuclear Structures
2.6K
2.6K
01:08Conjugate Addition of Enolates: Michael Addition
3.7K
The attack of a nucleophile at the β carbon of an α,β-unsaturated carbonyl compound is called conjugate addition. Conjugate addition reactions of active methylene compounds, such as β-diketones, β-keto esters, β-keto nitriles, and α-nitro ketones, are called Michael addition reactions.
3.7K