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Potentials of PKC in Cancer Progression and Anticancer Drug Development

Suman J Deka1, Vishal Trivedi1

  • 1Department of Biosciences and Bioengineering, Indian Institute of Technology-Guwahati, Guwahati-781039, Assam, India.

Current Drug Discovery Technologies
|February 23, 2018
PubMed

Insights

Protein kinase C (PKC) is crucial in cancer signaling and cell biology. This review explores PKC as an anti-cancer drug target and its regulators for therapeutic development.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Biology

Background:

  • Protein kinase C (PKC) is a family of serine-threonine kinases vital for mammalian cell signaling.
  • PKC regulates critical pathways involved in cell proliferation and apoptosis.
  • Dysregulation of PKC signaling is implicated in various cancers.

Purpose of the Study:

  • To review the potential of PKC as a target for anti-cancer therapies.
  • To identify and evaluate molecules that regulate PKC activity.
  • To assess the suitability of these regulators as anti-cancer drug candidates.

Main Methods:

  • Literature review of PKC research.
  • Analysis of known PKC regulators (activators and inhibitors).
  • Evaluation of therapeutic potential based on PKC modulation.

Main Results:

  • PKC plays a significant role in cancer-associated signaling pathways.
  • Numerous molecules have been identified as PKC regulators.
  • Some regulators show promise for anti-cancer drug development targeting PKC.

Conclusions:

  • PKC represents a promising target for novel anti-cancer drug development.
  • Further investigation into PKC regulators may yield effective cancer therapeutics.
  • Targeting PKC offers a potential strategy to modulate cancer cell proliferation and apoptosis.
Keywords:
Agonistantagonistscancermetastasisprotein kinase Csignal transduction.

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