Fontan-Associated Liver Disease: A Review
Luis Téllez1, Enrique Rodríguez-Santiago1, Agustín Albillos1
1Hospital Universitario Ramón y Cajal. Universidad de Alcalá. Servicio de Gastroenterología y Hepatología.
Annals of Hepatology
|February 23, 2018
Summary
Fontan-associated liver disease, a consequence of Fontan surgery, can lead to serious complications. Early diagnosis and management are crucial for preventing conditions like liver cancer and portal hypertension in Fontan survivors.
Area of Science:
- Cardiology
- Hepatology
- Pediatric Surgery
Background:
- Fontan-associated liver disease (FALD) stems from hemodynamic changes post-Fontan surgery.
- Histological liver changes in FALD resemble but differ from other cardiac liver diseases.
- The natural history of FALD is not fully understood, but complications are common.
Purpose of the Study:
- To review current knowledge on Fontan-associated liver disease pathophysiology.
- To update on the management strategies for FALD.
- To highlight new diagnostic methods and treatments for FALD.
Main Methods:
- Literature review of Fontan-associated liver disease.
- Analysis of hemodynamic changes and systemic venous congestion.
- Evaluation of diagnostic and treatment modalities.
Main Results:
- FALD patients face risks of ascites, variceal hemorrhage, and encephalopathy.
- Fontan survivors have an elevated risk of hepatocellular carcinoma.
- Early detection of advanced FALD is vital for preventing complications.
Conclusions:
- FALD requires vigilant monitoring and timely intervention.
- Advances in diagnostics and treatment offer improved patient outcomes.
- Understanding FALD pathophysiology is key to effective management.
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