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[Keratoderma with epidermolytic hyperkeratosis].

A Woscoff, J G Casas, E Dancziger

    Medicina Cutanea Ibero-Latino-Americana
    |January 1, 1986
    PubMed
    Summary
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    This study reports a family with Thost-Unna keratoderma and epidermolytic hyperkeratosis. Treatment with oral aromatic retinoids improved skin but caused erosions, necessitating discontinuation.

    Area of Science:

    • Dermatology
    • Genetics
    • Histopathology

    Background:

    • Thost-Unna keratoderma is a rare inherited skin disorder.
    • Epidermolytic hyperkeratosis is a condition characterized by abnormal keratinization.
    • The association between these two conditions is not fully understood.

    Observation:

    • Three family members presented with Thost-Unna keratoderma and epidermolytic hyperkeratosis.
    • Literature review included cases of keratoderma with similar histopathological findings.
    • Treatment with oral aromatic retinoids initially improved hyperkeratosis.

    Findings:

    • Aromatic retinoid treatment led to skin erosions and discomfort, requiring discontinuation.
    • The study highlights the potential for adverse effects even with improved hyperkeratosis.

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  • Histopathological examination is crucial for accurate diagnosis.

    • Implications:

    • Increased recognition of the association between keratoderma and epidermolytic hyperkeratosis is needed.
    • Careful monitoring is essential during retinoid therapy for such conditions.
    • Further research may elucidate optimal treatment strategies for this specific dermatosis.