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Molecular characterization and multidisciplinary management of Gerbich hemolytic disease of the newborn

Rebecca N Levitt1, Elise Gourri2, Christoph Gassner2

  • 1Department of Pediatrics, Inova Children's Hospital, Falls Church, Virginia.

Pediatric Blood & Cancer
|February 23, 2018
PubMed

Gerbich (Ge) antigens are high frequency red cell antigens expressed on glycophorin C (GYPC) and glycophorin D. Hemolytic disease of the fetus and newborn (HDFN) due to Gerbich antibody is rare and presents a clinical challenge, as Gerbich negative blood is scarce. We report a case of HDFN due to maternal Ge3 negative phenotype and anti-Ge3 alloimmunization, successfully managed by transfusion of maternal blood. Molecular testing revealed that the mother has homozygous deletion of exon 3 of GYPC, the father is homozygous wildtype for GYPC, and the infant is obligate heterozygote expressing Ge3.

Keywords:
GYPCGeGerbichHDFNHDNanti-Ge3hemolytic disease of the fetus and newbornmaternal alloimmunizationmaternal blood transfusion

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