Related Experiment Video

Updated: Feb 14, 2026

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy
07:10

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy

Published on: June 18, 2020

22.9K

[Analysis of coagulation related parameters between patients with advanced schistosomiasis cirrhosis and hepatitis B

Liu Shun1, Qin Meng2, Tang Shao-Qian1

  • 1The Second Clinical Medical College, Yangtze University, Jingzhou Central Hospital, Jingzhou 434020, China.

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi = Chinese Journal of Schistosomiasis Control
|February 23, 2018
PubMed

Insights

Coagulation parameters differ between schistosomiasis and hepatitis B cirrhosis patients. Hepatitis B cirrhosis shows more significant coagulation impairment with milder liver dysfunction, while advanced stages present distinct patterns in specific coagulation factors.

Area of Science:

  • Hepatology
  • Hematology
  • Infectious Diseases

Background:

  • Cirrhosis, a late stage of liver disease, significantly impacts coagulation. Differentiating coagulation profiles between various etiologies like schistosomiasis and hepatitis B is crucial for patient management.
  • Coagulation abnormalities are common in cirrhosis, affecting prothrombin time (PT), international normalized ratio (INR), fibrinogen (Fib), thrombin time (TT), activated partial thromboplastin time (APTT), and platelet count (PLT).

Purpose of the Study:

  • To compare coagulation parameter differences between advanced schistosomiasis cirrhosis and hepatitis B cirrhosis patients across varying liver function severities.
  • To provide evidence for better clinical assessment and prognosis prediction in these patient groups.

Main Methods:

  • A comparative study involving 63 advanced schistosomiasis cirrhosis patients, 80 hepatitis B cirrhosis patients, and 96 controls.
  • Measurement and comparison of PT, INR, Fib, TT, APTT, and PLT levels in the three groups and stratified by Child-Pugh liver function classes.

Main Results:

  • Significant differences in PT, INR, Fib, TT, APTT, and PLT were observed among the three groups (P < 0.05).
  • Both cirrhosis groups exhibited prolonged PT, INR, TT, APTT, and lower PLT compared to controls (P < 0.05).
  • Hepatitis B cirrhosis patients showed longer PT, INR, TT, APTT, and lower Fib and PLT than schistosomiasis cirrhosis patients (P < 0.05). Coagulation factor differences varied with liver function severity.

Conclusions:

  • Coagulation function damage differs between schistosomiasis and hepatitis B cirrhosis.
  • Hepatitis B cirrhosis demonstrates more pronounced coagulation impairment with milder liver dysfunction, particularly in PLT reduction.
  • As liver function worsens, APTT significantly prolongs in hepatitis B cirrhosis, with less distinct differences in PLT and PT compared to schistosomiasis cirrhosis.
Abstract

Keywords:
Advanced schistosomiasisCirrhosisCoagulation functionHepatitis BPlatelet

More Related Videos

Monitoring of Systemic and Hepatic Hemodynamic Parameters in Mice16:09

Monitoring of Systemic and Hepatic Hemodynamic Parameters in Mice

Published on: October 4, 2014

17.1K
A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients05:01

A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients

Published on: October 17, 2017

7.5K

Related Concept Videos

Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
1.5K
Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
10.7K
Noncompartmental Analysis: Miscellaneous Pharmacokinetic Parameters00:54

Noncompartmental Analysis: Miscellaneous Pharmacokinetic Parameters

The noncompartmental approach is a widely used method in pharmacokinetics to assess drugs' behaviors in the body. It considers several factors, including clearance, bioavailability, and total volume of distribution.
One key aspect of the noncompartmental approach is determining a drug's total clearance. This can be done by dividing the drug dose by the area under the concentration-time curve from zero to infinity. The area under the concentration-time curve represents the drug's...
465
Sample Preparation for Analysis: Advanced Techniques01:08

Sample Preparation for Analysis: Advanced Techniques

Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
1.5K
Wave Parameters01:10

Wave Parameters

The simplest mechanical waves are associated with simple harmonic motion and repeat themselves for several cycles. These simple harmonic waves can be modeled using a combination of sine and cosine functions. Consider a simplified surface water wave that moves across the water's surface. Unlike complex ocean waves, in surface water waves, water moves vertically, oscillating up and down, whereas the disturbance of the wave moves horizontally through the medium. If a seagull is floating on the...
9.4K
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
281