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Related Concept Videos

Mesh Analysis01:20

Mesh Analysis

1.6K
Mesh analysis is a valuable method for simplifying circuit analysis using mesh currents as key circuit variables. Unlike nodal analysis, which focuses on determining unknown voltages, mesh analysis applies Kirchhoff's voltage law (KVL) to find unknown currents within a circuit. This method is particularly convenient in reducing the number of simultaneous equations that need to be solved.
A fundamental concept in mesh analysis is the definition of meshes and mesh currents. A mesh is a closed...
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Elasticity01:12

Elasticity

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Elasticity is the ability of an object to withstand the effects of distortion and to return to its original size and shape once the forces causing deformation are removed. When an elastic material deforms under the action of an external force, it experiences internal resistance to the deformation. However, if no external force is applied, it returns to its original state.
The elasticity of an object can be described by a stress-strain curve, which represents the relationship between stress...
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Plant Cell Wall02:43

Plant Cell Wall

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The plant cell wall gives plant cells shape, support, and protection. As a cell matures, its cell wall specializes according to the cell type. For example, the parenchyma cells of leaves possess only a thin, primary cell wall.
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Cell Size01:22

Cell Size

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Cell sizes vary widely among and within organisms. Bacterial cells range between 1-10 micrometers (μm)and are considerably smaller than most eukaryotic cells. The smallest bacteria are 0.1 μm in diameter—about a thousand times smaller than eukaryotic cells, which typically range from 10-100 μm.
Surface Area
Cells can take in nutrients and water via diffusion through the plasma membrane itself or through specific channels in the membrane. The area of the membrane surrounding...
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Abdominal Aorta01:25

Abdominal Aorta

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Once the aorta traverses the diaphragmatic plane at the aortic hiatus, it is known as the abdominal aorta. This anatomical structure is positioned leftward of the spinal column, encased within a cocoon of adipose tissue behind the peritoneal cavity. It terminates at the L4 vertebra, where it splits into the common iliac arteries. Prior to this bifurcation, the abdominal aorta gives rise to several vital branches.
The celiac trunk, a singular artery, divides into the left gastric artery, which...
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Mesh Analysis with Current Sources01:10

Mesh Analysis with Current Sources

2.0K
Mesh analysis becomes simpler when analyzing circuits with current sources, whether independent or dependent. The presence of current sources reduces the number of equations required for analysis. Two cases illustrate this:
Current Source in One Mesh: The analysis process is straightforward when a current source is found in only one mesh within the circuit. Mesh currents are assigned as usual, with the mesh containing the current source excluded from the analysis. Kirchhoff's voltage law...
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A Simple Critical-sized Femoral Defect Model in Mice
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A Simple Critical-sized Femoral Defect Model in Mice

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Elastic TPU Mesh as Abdominal Wall Inlay Significantly Reduces Defect Size in a Minipig Model.

D Heise1, R Eickhoff1, A Kroh1

  • 1Department of General, Visceral and Transplantation Surgery, RWTH Aachen University Hospital, Aachen, Germany.

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
|February 23, 2018
PubMed
Summary
This summary is machine-generated.

An elastic thermoplastic polyurethane (TPU) mesh effectively reduced ventral hernia size in a minipig model by utilizing mesh-mediated traction. This approach shows promise for open abdomen cases but involves a slightly increased foreign body response compared to non-elastic meshes.

Keywords:
defect sizeelastic thermoplastic polyurethane (TPU) meshinlayminipig modelopen abdomenpolyvinylidene fluoride (PVDF) mesh

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Area of Science:

  • Surgical Innovation
  • Biomaterials Science
  • Abdominal Wall Reconstruction

Background:

  • The open abdomen approach with mesh is used for severe sepsis.
  • Early fascial closure is often not feasible.
  • Mesh-mediated traction can condition minimized ventral hernias.

Purpose of the Study:

  • To evaluate an elastic thermoplastic polyurethane (TPU) mesh for abdominal wall inlay.
  • To assess its efficacy in a minipig model for open abdomen management.

Main Methods:

  • Ten minipigs received either an elastic TPU mesh or a non-elastic polyvinylidene fluoride (PVDF) mesh.
  • Abdominal wall defect size and mesh expansion were measured after 8 weeks.
  • Histological and immunohistochemical analyses were performed.

Main Results:

  • The TPU mesh group showed a significantly smaller fascial defect (4.5 cm vs. 7.4 cm).
  • Increased Ki67 positive and apoptotic cells were observed with the TPU mesh.
  • A higher collagen type I/III ratio was noted in the PVDF group.

Conclusions:

  • Elastic TPU mesh implantation is a promising method for reducing ventral hernia size via mesh-mediated traction.
  • This approach may aid in managing the open abdomen.
  • An increased foreign body reaction was associated with the TPU mesh compared to PVDF.