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Vitamin D Receptor Expression in Dogs.

J A Cartwright1, A G Gow1, E Milne1

  • 1Division of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies and The Roslin Institute, Hospital for Small Animals, Easter Bush Veterinary Centre, The University of Edinburgh, Roslin, United Kingdom.

Journal of Veterinary Internal Medicine
|February 23, 2018
PubMed
Summary

Vitamin D receptor (VDR) is expressed in many non-skeletal tissues in dogs, including the kidney and duodenum. Inflammation did not alter VDR expression in the canine small intestine.

Keywords:
Chronic enteropathyImmunohistochemistryInflammatory bowel diseaseTight junctions

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Area of Science:

  • Veterinary medicine
  • Molecular biology
  • Immunology

Background:

  • Low vitamin D levels are linked to various diseases in dogs.
  • Vitamin D functions via the vitamin D receptor (VDR).
  • Limited knowledge exists on VDR expression in non-skeletal canine tissues and its modulation by inflammation.

Purpose of the Study:

  • To identify non-skeletal canine tissues expressing the VDR.
  • To investigate VDR expression in the inflamed small intestine of dogs with chronic enteropathy (CE).

Main Methods:

  • VDR expression was assessed using immunohistochemistry (IHC) and quantitative real-time polymerase chain reaction (qPCR).
  • Thirteen non-skeletal tissues were analyzed from control dogs.
  • Duodenal biopsies from dogs with CE and healthy controls were compared.

Main Results:

  • VDR expression was highest in the kidney, duodenum, skin, ileum, and spleen.
  • Gastric and testicular tissues showed no VDR expression.
  • No significant difference in duodenal VDR expression was found between dogs with CE and healthy controls.

Conclusions:

  • Canine intestinal VDR expression is not downregulated by inflammation, contrary to findings in humans.
  • Further research is warranted to explore vitamin D's potential in modulating canine intestinal inflammation.