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Updated: Feb 14, 2026

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
Published on: August 22, 2017
Prediction of 19F NMR Chemical Shifts for Fluorinated Aromatic Compounds
Carla Saunders1, Mohammad B Khaled2, Jimmie D Weaver2
1Department of Chemistry , University of California-Davis , Davis , California 95616 , United States.
Abstract:
Scaling factors are reported for use in predicting 19F NMR chemical shifts for fluorinated (hetero)aromatic compounds with relatively low levels of theory. Our recommended scaling factors were developed using a curated data set of 52 compounds, with 100 individual 19F shifts spanning a range of 153 ppm. With a maximum deviation of 6.5 ppm between experimental and computed shifts, or 4% of the range tested, these scaling factors allow for the assignment of chemical shifts to specific fluorines in multifluorinated aromatics. The utility of this approach is highlighted by several structural reassignments.
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