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Updated: Feb 14, 2026

Kidney Regeneration in Adult Zebrafish by Gentamicin Induced Injury
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Gentamicin-Releasing Mesoporous ZnO Structures.

Marco Laurenti1, Valentina Cauda2

  • 1Department of Applied Science and Technology, Politecnico di Torino, C.so Duca degli Abruzzi 24, 10129 Turin, Italy. marco.laurenti@polito.it.

Materials (Basel, Switzerland)
|February 23, 2018
PubMed
Summary
This summary is machine-generated.

This study developed mesoporous zinc oxide (ZnO) structures for enhanced drug delivery. These structures effectively adsorbed and released the antibiotic gentamicin sulfate (GS), showing potential for orthopedic applications.

Keywords:
drug deliverygentamicin sulfatemesoporous structurezinc oxide

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Nanotechnology

Background:

  • Zinc oxide (ZnO) possesses biocompatible and biodegradable properties, with diverse morphologies exhibiting useful activities.
  • Existing ZnO nanomaterials show promise in biomedical applications like tissue regeneration and wound healing.
  • A key limitation of current ZnO structures is the lack of intrinsic mesoporosity, hindering drug loading and release studies.

Purpose of the Study:

  • To investigate the adsorption and release properties of high surface area, mesoporous ZnO structures.
  • To utilize mesoporous ZnO for the delivery of gentamicin sulfate (GS), an antibiotic crucial for orthopedic infections.
  • To explore the potential of engineered ZnO for controlled drug delivery applications.

Main Methods:

  • Fabrication of mesoporous ZnO via thermal oxidation of sputtered porous zinc layers.
  • Adsorption of gentamicin sulfate (GS) onto the mesoporous ZnO matrix.
  • In vitro evaluation of GS kinetic release profile over seven days.

Main Results:

  • Successfully synthesized high surface area, mesoporous ZnO structures.
  • Demonstrated effective adsorption of GS, achieving a maximum loading of 263 mg/g.
  • Observed fast in vitro release of GS via a simple diffusion mechanism.

Conclusions:

  • Mesoporous ZnO structures are suitable for adsorbing and releasing antibiotics like GS.
  • The developed ZnO material shows promise for controlled drug delivery systems, particularly in orthopedics.
  • Further engineering of pore and surface properties can enhance controlled release capabilities.