Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biosynthesis of Polysaccharides01:26

Biosynthesis of Polysaccharides

724
Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...
724
Adhesion01:14

Adhesion

44.7K
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow...
44.7K
Cell Adhesion in Plants01:14

Cell Adhesion in Plants

3.4K
Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
3.4K
Role of Affect in Interpersonal Attraction01:24

Role of Affect in Interpersonal Attraction

239
Affect plays a crucial role in shaping interpersonal evaluations and perceptions. Emotions influence how individuals judge and respond to others, often determining whether interactions are viewed positively or negatively. This effect can manifest directly through interactions with the person in question or indirectly via associations with unrelated emotional experiences.Direct Effects of Affect on AttractionAffect directly influences interpersonal attraction when a person’s behavior...
239
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

4.4K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
4.4K
Cellulose and Pectic Polysaccharides01:15

Cellulose and Pectic Polysaccharides

5.0K
 Every plant cell has a cell wall that protects the cell, provides structural support, and gives the cell shape. Cellulose, the main structural component of the plant cell wall, makes up over 30% of plant matter. It is the most abundant organic compound on earth.  Cellulose is an unbranched polysaccharide composed of linear chains of glucose molecules linked by β (1→4) glycosidic bonds.
As a cell matures, its cell wall specializes according to its type. For example, the...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protease suppression by native I9 inhibitor improves recombinant protein production in Trichoderma reesei.

Bioresource technology·2026
Same author

Sex-specific associations between long-term exposure to ambient air pollution and the cardiac conduction system - a longitudinal analysis of the KORA cohort.

International journal of hygiene and environmental health·2026
Same author

Infrastructure and policy reforms to facilitate collaboration in medical research.

Nature reviews. Nephrology·2026
Same author

Respiratory signal extraction from the electrocardiogram for risk stratification in cardiac patients.

European heart journal. Digital health·2026
Same author

Mapping internal and lateral anterior intercostal artery perforator flaps with colour Doppler ultrasound: correlation between preoperative imaging and intraoperative findings in oncoplastic breast surgery.

Archives of gynecology and obstetrics·2026
Same author

Succinate supplementation ameliorates musculoskeletal defects caused by PLOD3 mutations in a BCARD syndrome model.

Genome medicine·2026

Related Experiment Video

Updated: Feb 14, 2026

Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots
05:43

Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots

Published on: January 13, 2023

4.5K

Stimuli-Responsive Multilayers Based on Thiolated Polysaccharides That Affect Fibroblast Cell Adhesion.

Pegah Esmaeilzadeh1,2, Alexander Köwitsch1, Andrea Liedmann1

  • 1Biomedical Materials Group, Institute of Pharmacy , Martin Luther University Halle-Wittenberg , Heinrich Damerow Strasse 4 , 06120 Halle (Saale) , Germany.

ACS Applied Materials & Interfaces
|February 23, 2018
PubMed
Summary

Stimuli-responsive multilayers of thiolated chitosan and chondroitin sulfate were created. These novel nanostructures show tunable properties and enhanced cell adhesion, promising for tissue engineering and wound healing.

Keywords:
fibroblast adhesionfibronectin adsorptionmultilayerspolyelectrolytesstimuli-responsive biomaterialsthiolated chitosanthiolated chondroitin sulfate

More Related Videos

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm
12:12

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

Published on: May 14, 2014

11.0K
Using Multilayered Hydrogel Bioink in Three-Dimensional Bioprinting for Homogeneous Cell Distribution
06:29

Using Multilayered Hydrogel Bioink in Three-Dimensional Bioprinting for Homogeneous Cell Distribution

Published on: May 2, 2020

7.1K

Related Experiment Videos

Last Updated: Feb 14, 2026

Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots
05:43

Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots

Published on: January 13, 2023

4.5K
Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm
12:12

Irrelevant Stimuli and Action Control: Analyzing the Influence of Ignored Stimuli via the Distractor-Response Binding Paradigm

Published on: May 14, 2014

11.0K
Using Multilayered Hydrogel Bioink in Three-Dimensional Bioprinting for Homogeneous Cell Distribution
06:29

Using Multilayered Hydrogel Bioink in Three-Dimensional Bioprinting for Homogeneous Cell Distribution

Published on: May 2, 2020

7.1K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Stimuli-responsive polymeric platforms are crucial for advanced biomedical applications.
  • Controlling biomaterial properties via external stimuli enables tailored functionalities.
  • Layer-by-layer assembly is a versatile technique for fabricating complex multilayer structures.

Purpose of the Study:

  • To fabricate and characterize a novel stimuli-responsive multilayer system using thiolated chitosan and thiolated chondroitin sulfate.
  • To investigate the cross-linking behavior and property modulation of the multilayer system in response to pH and chemical stimuli.
  • To evaluate the potential of these nanostructures for biomedical applications, particularly in cell adhesion and tissue regeneration.

Main Methods:

  • Fabrication of a five-bilayer system ([t-Chi/t-CS]5) using layer-by-layer assembly.
  • Stimuli-induced cross-linking of thiol groups using a pH increase (4 to 9.3) and chloramine-T (ChT).
  • Comprehensive characterization of multilayer properties including thiol content, wettability, surface charge, mechanical properties, and fibronectin binding.

Main Results:

  • The [t-Chi/t-CS]5 multilayers exhibited stimuli-dependent changes in physical and chemical properties after pH and ChT treatments.
  • Chloramine-T treatment resulted in more significant changes and superior cell adhesion compared to pH-induced cross-linking.
  • Human dermal fibroblast studies confirmed the enhanced cell-adhesive potential of ChT-responsive multilayers.

Conclusions:

  • The fabricated [t-Chi/t-CS]5 multilayer system demonstrates effective stimuli-responsive behavior through disulfide bond formation.
  • These tunable nanostructures offer potential for applications in wound healing and tissue engineering by controlling cell interactions and facilitating controlled release.
  • The ability to modulate material properties via pH or redox stimuli opens avenues for designing advanced biomaterials.