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Toward true closed-loop neuromodulation: artifact-free recording during stimulation.
Andy Zhou1, Benjamin C Johnson1, Rikky Muller1
1Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, 2108 Allston Way, Suite 200, Berkeley, CA 94704, United States.
Current Opinion in Neurobiology
|February 23, 2018
Summary
Closed-loop neuromodulation requires simultaneous recording and stimulation. Overcoming stimulation artifacts is crucial for adaptive, on-demand neural therapies and advancing responsive neurostimulation systems.
Area of Science:
- Biomedical Engineering
- Neuroscience
- Medical Devices
Background:
- Closed-loop neuromodulation offers adaptive, on-demand therapy by responding to neural activity.
- Effective closed-loop systems require simultaneous neural recording and stimulation.
- Stimulation artifacts currently hinder simultaneous recording and stimulation by obscuring neural biomarkers.
Purpose of the Study:
- To review state-of-the-art techniques for artifact cancellation in neuromodulation.
- To highlight the importance of co-designing and integrating artifact cancellation methods.
- To enable artifact-free simultaneous stimulation and recording for advanced neuromodulation systems.
Main Methods:
- Review of artifact-preventing system configurations.
- Analysis of resilient recording front-end technologies.
- Evaluation of back-end signal processing for artifact removal.
Main Results:
- Several techniques exist to mitigate stimulation artifacts.
- Integrated artifact cancellation is essential for simultaneous recording and stimulation.
- Advancements in system configurations, recording hardware, and signal processing are key.
Conclusions:
- Co-designing and integrating artifact cancellation techniques are critical for effective closed-loop neuromodulation.
- Artifact-free neuromodulation will enable more responsive and adaptive neural therapies.
- This review provides a roadmap for developing next-generation neuromodulation systems.
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