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Related Concept Videos

What is the Cell Cycle?00:56

What is the Cell Cycle?

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The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the...
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What is the Cell Cycle?01:04

What is the Cell Cycle?

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The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
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The Cell Cycle Control System01:28

The Cell Cycle Control System

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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
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The Cell Cycle Control System02:11

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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

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The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
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Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
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Molecular Cogs: Interplay between Circadian Clock and Cell Cycle.

Jonathan Gaucher1, Emilie Montellier1, Paolo Sassone-Corsi1

  • 1Center for Epigenetics and Metabolism, U1233 INSERM, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.

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The cell cycle and circadian clock are biological oscillators with molecular links. Understanding their interplay is crucial for cancer research and developing new cancer therapies.

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Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter
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In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters
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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Chronobiology

Background:

  • The cell cycle and circadian clock are fundamental biological oscillators regulating cellular functions.
  • Both systems are frequently dysregulated in cancer, suggesting a link between them.
  • Evidence points to molecular connections and common regulators between these two oscillators.

Purpose of the Study:

  • To explore the molecular interplay between the cell cycle and the circadian clock.
  • To investigate the significance of this connection in the context of cancer biology.
  • To identify potential therapeutic targets based on the crosstalk between these oscillators.

Main Methods:

  • Literature review of studies investigating cell cycle and circadian clock interactions.
  • Analysis of molecular mechanisms, including common regulators and coupling pathways.
  • Examination of cancer genomics data for evidence of co-dysregulation.

Main Results:

  • Identified shared regulatory elements and signaling pathways linking the cell cycle and circadian clock.
  • Highlighted the frequent misregulation of both oscillators in various cancer types.
  • Demonstrated that the interplay between these oscillators influences cell proliferation and cancer development.

Conclusions:

  • The cell cycle and circadian clock are intricately linked through molecular mechanisms.
  • Dysregulation of this crosstalk is a hallmark of cancer, offering therapeutic opportunities.
  • Further research into these connections may lead to novel anti-cancer strategies.