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Immobilized fibrinogen activates human platelets through glycoprotein VI

Pierre H Mangin1, Marie-Blanche Onselaer2, Nicolas Receveur3

  • 1Université de Strasbourg, INSERM, EFS Grand-Est, BPPS UMR-S 1255, FMTS, France pierre.mangin@efs.sante.fr s.p.watson@bham.ac.uk.

Haematologica
|February 24, 2018
PubMed
Summary

Glycoprotein VI (GPVI) binds fibrinogen, a key interaction for platelet activation and aggregation. This finding reveals GPVI as a potential target for developing novel antithrombotic therapies.

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