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Related Experiment Videos

An experimental evaluation of microcapsules for arterial chemoembolization.

W Bechtel, K C Wright, S Wallace

    Radiology
    |December 1, 1986
    PubMed
    Summary

    Microcapsules containing floxuridine (FUDR) showed varied drug release and kidney effects based on material. Cellulose polymer capsules caused no damage, while lactide polymer capsules induced significant changes.

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    Area of Science:

    • Biomedical Engineering
    • Drug Delivery Systems
    • Oncology

    Background:

    • Intraarterial chemotherapy offers localized cancer treatment.
    • Microencapsulation is a promising method for controlled drug release.
    • Developing effective microcapsule materials is crucial for transcatheter therapies.

    Purpose of the Study:

    • To evaluate the drug release profiles and histological effects of various microcapsule materials loaded with floxuridine (FUDR).
    • To assess the suitability of different microencapsulation materials for intraarterial delivery in a canine kidney model.

    Main Methods:

    • Microcapsules (50-350 micron) made of monoglyceride, monodiglyceride, natural wax, cellulose polymer, or lactic acid polymer, with or without FUDR, were prepared.
    • These microcapsules were intraarterially injected into canine kidneys.

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  • Renal and systemic venous blood samples were analyzed over 6 hours to determine drug release.
  • Kidney histology was examined to assess tissue response.

    • Main Results:

    • Drug release from microcapsules was either uniphasic or multiphasic, dependent on the capsular material.
    • Histological examination revealed varying degrees of kidney damage in all embolized kidneys, except those treated with cellulose polymer capsules.
    • Lactide polymer capsules resulted in the most pronounced histological changes.

    Conclusions:

    • The choice of capsular material significantly influences the drug release kinetics and biological effects of microencapsulated FUDR.
    • Cellulose polymer microcapsules appear to be a safe option, causing minimal histological damage.
    • Lactide polymer microcapsules demonstrate potent effects, warranting further investigation for targeted chemotherapy.