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Modulating bacterial and gut mucosal interactions with engineered biofilm matrix proteins

Anna M Duraj-Thatte1,2, Pichet Praveschotinunt1,2, Trevor R Nash1,2

  • 1Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, United States.

Scientific Reports
|February 24, 2018
PubMed
Summary

Engineered curli fibers display human cytokines to modulate host-microbe interactions. These bacterial matrix proteins can program biofilm properties and influence host cell behavior, offering a new approach to manipulating mucosal immunity.

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