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Levosulpiride-induced Movement Disorders.

Supriyo Choudhury1, Koustav Chatterjee1, Ravi Singh1

  • 1Department of Neurology, RGC Research Centre, Institute of Neurosciences, Kolkata, West Bengal, India.

Journal of Pharmacology & Pharmacotherapeutics
|February 24, 2018
PubMed
Summary
This summary is machine-generated.

Levetiracetam (LSP) can cause movement disorders like dyskinesia and parkinsonism. These drug-induced movement disorders are often difficult to treat and may not fully resolve.

Keywords:
Adverse drug reactionantipsychoticdyskinesialevosulpiridemovement disordersparkinsonism

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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Levetiracetam (LSP) is an antiepileptic drug with a known side effect profile.
  • Movement disorders are a potential, though less common, adverse drug reaction to LSP.

Observation:

  • This report details one case of acute onset LSP-induced parkinsonism in a 56-year-old female.
  • Ten additional cases of LSP-induced dyskinesia are summarized, with a mean patient age of 65.3 years.
  • Patients had taken LSP for a median of 13 months before symptom onset.

Findings:

  • Causality of LSP as an adverse drug reaction was systematically assessed using a validated rating system.
  • Clinical presentations of dyskinesia were extensively qualified using a clinical rating scale.
  • LSP-induced dyskinesia presented a treatment challenge, with often incomplete resolution.

Implications:

  • Clinicians should be aware of the potential for LSP to induce various movement disorders.
  • Early recognition and management are crucial for patients experiencing LSP-induced movement abnormalities.
  • Further research may be needed to optimize treatment strategies for these challenging adverse drug reactions.