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Levosulpiride-induced Movement Disorders
Supriyo Choudhury1, Koustav Chatterjee1, Ravi Singh1
1Department of Neurology, RGC Research Centre, Institute of Neurosciences, Kolkata, West Bengal, India.
Journal of Pharmacology & Pharmacotherapeutics
|February 24, 2018
Summary
Levetiracetam (LSP) can cause movement disorders like dyskinesia and parkinsonism. These drug-induced movement disorders are often difficult to treat and may not fully resolve.
Area of Science:
- Neurology
- Pharmacology
Background:
- Levetiracetam (LSP) is an antiepileptic drug with a known side effect profile.
- Movement disorders are a potential, though less common, adverse drug reaction to LSP.
Observation:
- This report details one case of acute onset LSP-induced parkinsonism in a 56-year-old female.
- Ten additional cases of LSP-induced dyskinesia are summarized, with a mean patient age of 65.3 years.
- Patients had taken LSP for a median of 13 months before symptom onset.
Findings:
- Causality of LSP as an adverse drug reaction was systematically assessed using a validated rating system.
- Clinical presentations of dyskinesia were extensively qualified using a clinical rating scale.
- LSP-induced dyskinesia presented a treatment challenge, with often incomplete resolution.
Implications:
- Clinicians should be aware of the potential for LSP to induce various movement disorders.
- Early recognition and management are crucial for patients experiencing LSP-induced movement abnormalities.
- Further research may be needed to optimize treatment strategies for these challenging adverse drug reactions.
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