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Elevated zinc concentrations in a 5 months old infant: A case report
Eva Rabing Brix Petersen1, Sven Mortensen2, Mads Nybo1
1Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.
Elevated zinc levels in an infant were caused by external contamination from zinc oxide ointment applied to the capillary blood sampling site. This highlights the importance of considering pre-analytical contamination in laboratory diagnostics.
Area of Science:
- Clinical Chemistry
- Laboratory Medicine
- Pediatric Diagnostics
Background:
- Pre-analytical errors represent a significant portion of laboratory-associated errors.
- Accurate laboratory testing is crucial for effective patient diagnosis and management.
Observation:
- An infant exhibited unexpectedly high serum zinc concentrations (20.2 µmol/L, rising to 42.4 µmol/L) during routine testing.
- No clinical signs of zinc toxicity were present, and laboratory assay performance was satisfactory.
Findings:
- The elevated zinc levels were traced to the application of a vitamin E ointment containing zinc oxide at the capillary blood collection site.
- Subsequent blood sampling from an uncontaminated site yielded a normal zinc concentration (14.3 µmol/L).
Implications:
- External contamination, particularly from topical ointments, can significantly impact capillary blood sample results.
- Healthcare professionals must be vigilant for pre-analytical contamination sources to ensure diagnostic accuracy.
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