Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

6.9K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
6.9K
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

5.8K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
5.8K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

3.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.6K
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

930
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
930
Retroviruses02:33

Retroviruses

15.0K
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
15.0K
Bacterial Transformation01:33

Bacterial Transformation

60.2K
In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
60.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CRISPR and Beyond: Genome-Editing Strategies in Retinal Stem Cell Research.

Cells·2026
Same author

Metabolic Syndrome-Driven Changes in Cardiac Lymphatic Endothelium: mRNA Expression and Emerging Questions.

Pathophysiology : the official journal of the International Society for Pathophysiology·2026
Same author

The Immunobiology of Dry Eye Disease: A Review of the Pathogenesis, Regulation and Therapeutic Implications.

International journal of molecular sciences·2025
Same author

Targeting Metabolic Dysregulation in Obesity and Metabolic Syndrome: The Emerging Role of N-Acetylcysteine.

Metabolites·2025
Same author

Immunological Insights and Therapeutic Advances in COPD: Exploring Oral Bacterial Vaccines for Immune Modulation and Clinical Improvement.

Vaccines·2025
Same author

The Ocular Surface and the Anterior Segment of the Eye in the Pseudoexfoliation Syndrome: A Comprehensive Review.

International journal of molecular sciences·2025

Related Experiment Video

Updated: Feb 14, 2026

Rat Mesentery Angiogenesis Assay
18:30

Rat Mesentery Angiogenesis Assay

Published on: June 18, 2011

14.2K

Angiogenesis modulation by exogenous antioxidants.

Dorota Magdalena Radomska-Leśniewska1, Barbara Joanna Bałan2, Piotr Skopiński1

  • 1Department of Histology and Embryology, Biostructure Centre, Medical University of Warsaw, Poland.

Central-European Journal of Immunology
|February 24, 2018
PubMed
Summary

Exogenous antioxidants impact blood vessel formation (angiogenesis). While many synthetic and some natural antioxidants inhibit excessive angiogenesis, others, like purple coneflower, can normalize it, aiding disease treatment.

Keywords:
angiogenesisangiomodulatory propertiesnatural antioxidantsplant origin antioxidantsreactive oxygen speciessynthetic antioxidants

More Related Videos

In Vitro Model of Coronary Angiogenesis
08:03

In Vitro Model of Coronary Angiogenesis

Published on: March 10, 2020

8.5K
A Generalized Method for Determining Free Soluble Phenolic Acid Composition and Antioxidant Capacity of Cereals and Legumes
10:30

A Generalized Method for Determining Free Soluble Phenolic Acid Composition and Antioxidant Capacity of Cereals and Legumes

Published on: June 10, 2022

8.2K

Related Experiment Videos

Last Updated: Feb 14, 2026

Rat Mesentery Angiogenesis Assay
18:30

Rat Mesentery Angiogenesis Assay

Published on: June 18, 2011

14.2K
In Vitro Model of Coronary Angiogenesis
08:03

In Vitro Model of Coronary Angiogenesis

Published on: March 10, 2020

8.5K
A Generalized Method for Determining Free Soluble Phenolic Acid Composition and Antioxidant Capacity of Cereals and Legumes
10:30

A Generalized Method for Determining Free Soluble Phenolic Acid Composition and Antioxidant Capacity of Cereals and Legumes

Published on: June 10, 2022

8.2K

Area of Science:

  • Biochemistry
  • Physiology
  • Pharmacology

Background:

  • Redox homeostasis, maintained by endogenous and exogenous defense systems, is crucial for health.
  • Oxidative stress is implicated in diseases like cancer and ischemic heart disease, often disrupting angiogenesis.
  • Antioxidants can influence neovascularization, potentially modulating disease progression and therapy outcomes.

Purpose of the Study:

  • To review the impact of exogenous antioxidants on angiogenesis.
  • To explore factors that modulate antioxidant-influenced neovascularization.
  • To assess the therapeutic potential of antioxidants in diseases involving aberrant angiogenesis.

Main Methods:

  • Literature review of studies on exogenous antioxidants and their effects on neovascularization.
  • Analysis of synthetic and natural antioxidants' mechanisms of action on angiogenesis.
  • Evaluation of antioxidant preparations with regulatory effects on angiogenesis.

Main Results:

  • Most synthetic antioxidants (e.g., N-acetylcysteine, pentoxifylline, synthetic curcumin, synthetic EGCG, tripertenoids) inhibit neovascularization.
  • Natural antioxidants like resveratrol and EGCG also show inhibitory effects on excessive angiogenesis.
  • Certain natural antioxidants (purple coneflower) and preparations (Padma 28, Immunal forte) can normalize both low and high levels of angiogenesis.

Conclusions:

  • Exogenous antioxidants have a significant, varied impact on angiogenesis.
  • Therapeutic application of antioxidants may normalize aberrant neovascularization in various diseases.
  • Natural antioxidants and specific preparations offer a regulatory approach to managing angiogenesis-related conditions.