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Deciphering the roles of FOXO1 in human neoplasms

Shuai Jiang1,2, Tian Li3, Zhi Yang3

  • 1Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi'an, 710069, China.

International Journal of Cancer
|February 24, 2018
PubMed

Insights

Neoplasms cause millions of deaths globally. This review highlights the anti-cancer functions of the FOXO1 (forkhead box O1) protein, suggesting its potential as a therapeutic target for cancer treatment.

Area of Science:

  • Oncology and Molecular Biology

Background:

  • Neoplasms represent a significant global health burden, causing millions of deaths annually.
  • The forkhead box O1 (FOXO1) protein is a key transcriptional factor regulating various cellular processes.

Purpose of the Study:

  • To review recent research on the anti-neoplastic roles of FOXO1.
  • To identify FOXO1 as a potential therapeutic target for cancer treatment.

Main Methods:

  • Literature review of recent studies on FOXO1 in neoplasms.

Main Results:

  • FOXO1 plays a significant role in suppressing tumor development.
  • Evidence suggests FOXO1's involvement in multiple anti-cancer mechanisms.

Conclusions:

  • FOXO1 exhibits potent anti-neoplastic properties.
  • Targeting FOXO1 may offer a promising therapeutic strategy for managing neoplasms.
Keywords:
Forkhead box O1apoptosismicroRNAneoplasmphosphorylationproliferation

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