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Determination of Nanoparticle Size Using a Flow Particle-Tracking Method.

Yusuke Matsuura1, Ayako Nakamura1, Haruhisa Kato1

  • 1National Metrology Institute of Japan , National Institute of Advanced Industrial Science and Technology , Tsukuba Central 5, Higashi 1-1-1 , Tsukuba , Ibaraki 305-8565 , Japan.

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Summary

We developed a novel flow particle-tracking (FPT) method to accurately measure nanoparticle size under flow. This technique bypasses calibration, offering reliable mean size determination for diverse nanomaterials.

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Physical Chemistry

Background:

  • Current liquid particle counting methods for nanoparticle sizing under flow rely on light scattering intensity.
  • These methods require calibration with size standards, introducing material-dependent variability and limitations.
  • Accurate nanoparticle characterization under dynamic flow conditions is crucial for applications in microfluidics and synthesis.

Purpose of the Study:

  • To develop a novel, calibration-free method for determining the mean size of nanoparticles under flow conditions.
  • To overcome the limitations of existing light scattering-based sizing techniques.
  • To enable reliable nanoparticle sizing applicable to any material type.

Main Methods:

  • Introduction of the flow particle-tracking (FPT) method, which observes individual particle Brownian motion.
  • Determination of the flow velocity profile within the sample cell by analyzing particle motion.
  • Calculation of the self-diffusion coefficient for each particle and subtraction of flow velocity effects to obtain accurate sizing.

Main Results:

  • The FPT method reliably determines nanoparticle mean size under flow conditions based on the Stokes-Einstein assumption.
  • The method successfully isolates Brownian motion from bulk flow, enabling accurate size determination.
  • Demonstrated independence from size standard calibration, allowing application to various nanomaterial types.

Conclusions:

  • The developed FPT method provides a robust and versatile approach for nanoparticle sizing in flow.
  • This technique eliminates the need for material-specific calibration, enhancing applicability.
  • The FPT method holds significant potential for advancing microchannel reaction and synthesis devices utilizing nanomaterials.