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Primary aldosteronism and thyroid disorders in atrial fibrillation: A Swedish nationwide case-control study

Georgios Mourtzinis1,2, Samuel Adamsson Eryd1,3, Annika Rosengren1,3

  • 11 Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.

European Journal of Preventive Cardiology
|February 24, 2018
PubMed

Insights

Patients with atrial fibrillation have double the prevalence of primary aldosteronism compared to the general population. This study also found higher rates of hypothyroidism and hyperthyroidism in atrial fibrillation patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Epidemiology

Background:

  • Atrial fibrillation is linked to hyperthyroidism.
  • Primary aldosteronism is associated with atrial fibrillation, but its prevalence in this patient group is unknown.
  • Thyroid disorders are common comorbidities in cardiovascular conditions.

Purpose of the Study:

  • To determine the prevalence of primary aldosteronism in patients with atrial fibrillation.
  • To compare the prevalence of primary aldosteronism and thyroid disorders in atrial fibrillation patients versus controls.
  • To investigate the association between atrial fibrillation and endocrine disorders.

Main Methods:

  • Nationwide case-control study in Sweden (1987-2013).
  • Identified 713,569 atrial fibrillation cases.
  • Matched controls (1:2 ratio) from the Swedish Total Population Register.

Main Results:

  • Primary aldosteronism prevalence was 0.056% in atrial fibrillation patients vs. 0.024% in controls.
  • Hypothyroidism prevalence was 5.9% in atrial fibrillation patients vs. 3.7% in controls.
  • Hyperthyroidism prevalence was 2.3% in atrial fibrillation patients vs. 0.8% in controls.

Conclusions:

  • This study reveals a doubled prevalence of primary aldosteronism in atrial fibrillation patients.
  • Increased prevalence of hypothyroidism and hyperthyroidism was observed in atrial fibrillation patients.
  • Highlights the importance of screening for primary aldosteronism and thyroid disorders in atrial fibrillation.

Keywords:
Atrial fibrillationhyperthyroidismhypothyroidismprevalenceprimary aldosteronism

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