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Allergoids for Allergy Treatment.

Jeronimo Carnes1, Maria T Gallego1, Raquel Moya1

  • 1R&D Department, Laboratorios LETI, Tres Cantos, Spain.

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|February 24, 2018
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Summary

Allergoids, chemically modified allergen extracts, offer reduced allergenicity while maintaining immunogenicity for effective allergy treatment. Their development involves polymerization, with recent advancements focusing on new modifications and adjuvants, ensuring a favorable safety profile.

Keywords:
Allergen immunotherapyallergoidscarbamylationcharacterizationclinical evidencedepigmented allergoidsformaldehydeglutaraldehydemechanism of actionmonomeric allergoidspolymerization.

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Area of Science:

  • Immunology
  • Allergology
  • Biochemistry

Background:

  • Allergoids are chemically modified allergen extracts designed to reduce allergenicity while preserving immunogenicity for allergy treatment.
  • Various methods for allergoid production have been explored, presenting promising research avenues.

Purpose of the Study:

  • To review allergoid development approaches.
  • To analyze allergoid characterization, mechanism of action, efficacy, and safety.
  • To examine recent patents and clinical evidence related to allergoids.

Main Methods:

  • Literature review and analysis of scientific publications and patents.
  • Focus on chemical modifications, particularly polymerization with aldehydes like formaldehyde or glutaraldehyde.
  • Discussion of updated information on mechanism of action, clinical evidence, and safety.

Main Results:

  • Allergoids are primarily produced by polymerizing native allergen extracts with aldehydes.
  • Recent research includes novel chemical modifications and the use of new adjuvants.
  • Characterization of allergoids necessitates advanced analytical techniques compared to native extracts.

Conclusions:

  • Allergoids demonstrate an excellent safety profile and a convenient rapid build-up phase for allergy treatment.
  • Partial understanding of their mechanism of action and growing clinical evidence support their efficacy.
  • Allergoids represent a valuable therapeutic option in managing allergic conditions.