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Updated: Feb 14, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
Published on: January 7, 2019
Should I offer vagus nerve stimulation as part of my neurology practice?
Kai M Denski1, David M Labiner1
1Department of Neurology, College of Medicine (KMD, DML), and Department of Pharmacy Practice & Science, College of Pharmacy (DML), The University of Arizona, Tucson.
Abstract:
Vagus nerve stimulation (VNS) is a safe and effective adjunctive therapy approved for patients with partial-onset seizures. A pulse generator, which is implanted in the chest wall, delivers programmed electrical pulses through an electrode that is attached to the left vagus nerve. VNS plays an important role in the treatment of patients with drug-resistant epilepsy. It is currently offered in academic as well as private practice settings. After a comprehensive workup is performed, VNS should be offered to patients with drug-resistant epilepsy who are not candidates for surgery.
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