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Updated: Feb 14, 2026

Genomic MRI - a Public Resource for Studying Sequence Patterns within Genomic DNA
Published on: May 9, 2011
MRI pattern approach of adult-onset inherited leukoencephalopathies
Pierre Labauge1, Clarisse Carra-Dalliere1, Nicolas Menjot de Champfleur1
1Departments of Neurology (PL, CC-D, XA) and Neuroradiology (NMdC), CHU Montpellier; and Neuropédiatrie et Maladies Métaboliques and INSERM U676 (OB-T), National Reference Center for Leukodystrophies, Hôpital Robert Debré, Assistance Publique-Hôpitaux de Paris-Université Paris Diderot, Paris, France.
Abstract:
White matter hyperintensities are frequently encountered in clinical practice. In adulthood, white matter hyperintensities are generally related to acquired disorders, such as vascular, inflammatory, or demyelinating diseases. Symmetrical and confluent white matter abnormalities on the first available MRI suggest a genetic disorder. In this article, we provide keys to recognize and classify the adult-onset forms of inherited leukoencephalopathies and to identify their causes by targeting specific biochemical or molecular biomarkers.
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