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[Sweet syndrome with immune complex vasculitis in a child]
Zeitschrift Fur Hautkrankheiten
|October 1, 1986
Summary
This case study details a rare instance of Sweet's syndrome (SS) in a child, characterized by fever, skin lesions, and vasculitis. Immunological findings suggest T-lymphocytes and macrophages play a role in the condition.
Area of Science:
- Pediatrics
- Dermatology
- Immunology
Background:
- Sweet's syndrome (SS) is an acute febrile neutrophilic dermatosis.
- It is characterized by fever, neutrophilia, and tender, erythematous cutaneous plaques.
Observation:
- A rare case of SS in a 7-year-old boy presented with high fever, arthralgia, and painful skin lesions.
- Histopathology revealed cutaneous small vessel vasculitis with IgM and C3 deposition.
Findings:
- Direct immunofluorescence confirmed vasculitis with immune complex deposition.
- Monoclonal antibody staining identified T-lymphocytes and macrophages in perivascular infiltrates during the delayed phase.
- Circulating immune complexes were detected in the patient's blood.
Implications:
- The findings provide insights into the immunological pathogenesis of Sweet's syndrome.
- This case highlights the potential therapeutic benefit of cyclooxygenase inhibitors in managing SS.