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PharmGKB: A worldwide resource for pharmacogenomic information
Julia M Barbarino1, Michelle Whirl-Carrillo1, Russ B Altman2,3
1Department of Biomedical Data Sciences, Stanford University, Stanford, California.
Wiley Interdisciplinary Reviews. Systems Biology and Medicine
|February 24, 2018
Summary
The Pharmacogenomics Knowledgebase (PharmGKB) is a vital, freely accessible resource for pharmacogenomic (PGx) information. It supports personalized medicine by providing genetic insights for drug treatment adjustments.
Area of Science:
- Genomic Medicine
- Translational Medicine
Background:
- Precision medicine is increasingly important in healthcare.
- Pharmacogenomics (PGx) is a growing field with expanding clinical applications and literature.
- Leading institutions are implementing PGx testing.
Purpose of the Study:
- To highlight the role and resources of the Pharmacogenomics Knowledgebase (PharmGKB).
- To emphasize PharmGKB's adaptation to the genomic medicine revolution.
- To underscore PharmGKB as a key resource for PGx knowledge.
Main Methods:
- The article reviews the PharmGKB website and its offerings.
- It describes the types of PGx information available.
- It discusses the accessibility and target audience of PharmGKB.
Main Results:
- PharmGKB provides diverse PGx information, including literature annotations and drug treatment guidelines.
- The resource is freely available to researchers, clinicians, and the public.
- PharmGKB has been a continuously vital resource for over 17 years.
Conclusions:
- PharmGKB remains a crucial, evolving resource for the pharmacogenomics community.
- Its comprehensive information supports the advancement of personalized medicine.
- The knowledgebase is essential for translating genomic discoveries into clinical practice.
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