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Related Concept Videos

Insomnia01:27

Insomnia

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Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
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Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

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Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
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Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence01:19

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence

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Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
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Alternative RNA Splicing02:18

Alternative RNA Splicing

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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Management of Insomnia01:19

Management of Insomnia

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The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies
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Do cannabinoids constitute a therapeutic alternative for insomnia?

Tania Contreras1, Gonzalo Bravo-Soto2, Gabriel Rada3

  • 1Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile.

Medwave
|February 24, 2018
PubMed
Summary
This summary is machine-generated.

Cannabinoids are being explored for insomnia treatment. However, current evidence is unclear on their effectiveness for sleep quality or severity and may be linked to frequent adverse effects.

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Area of Science:

  • Pharmacology
  • Sleep Medicine
  • Evidence-Based Medicine

Background:

  • Cannabinoids are being investigated as a potential therapeutic option for individuals experiencing insomnia.
  • The efficacy and safety of cannabinoids for sleep disorders require thorough evaluation.

Purpose of the Study:

  • To systematically review and meta-analyze the available evidence on the effects of cannabinoids on insomnia.
  • To assess the impact of cannabinoids on insomnia severity, sleep quality, and related parameters.

Main Methods:

  • A comprehensive search was conducted using Epistemonikos, a large database of systematic reviews.
  • Data from systematic reviews, including primary studies and randomized trials, were extracted and reanalyzed.
  • A meta-analysis was performed, and findings were summarized using the GRADE approach.

Main Results:

  • Eight systematic reviews encompassing three studies (two randomized trials) were identified.
  • Cannabinoids' effect on insomnia severity and sleep quality remains unclear.
  • No significant effect was observed on sleep consolidation, awakening, or wakefulness behavior.

Conclusions:

  • The current evidence does not support the use of cannabinoids for insomnia.
  • Cannabinoids are likely associated with a higher incidence of adverse effects.
  • Further high-quality research is needed to clarify the role of cannabinoids in sleep medicine.