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Updated: Feb 14, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
The multifaceted roles of perlecan in fibrosis
Megan S Lord1, Fengying Tang1, Jelena Rnjak-Kovacina1
1Graduate School of Biomedical Engineering, UNSW Sydney, NSW 2052, Australia.
Abstract:
Perlecan, or heparan sulfate proteoglycan 2 (HSPG2), is a ubiquitous heparan sulfate proteoglycan that has major roles in tissue and organ development and wound healing by orchestrating the binding and signaling of mitogens and morphogens to cells in a temporal and dynamic fashion. In this review, its roles in fibrosis are reviewed by drawing upon evidence from tissue and organ systems that undergo fibrosis as a result of an uncontrolled response to either inflammation or traumatic cellular injury leading to an over production of a collagen-rich extracellular matrix. This review focuses on examples of fibrosis that occurs in lung, liver, kidney, skin, kidney, neural tissues and blood vessels and its link to the expression of perlecan in that particular organ system.
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