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Updated: Feb 14, 2026
23:33
The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
84.6K
Multiple Thromboembolic Events from a Left Atrial Appendage Occlusion Device.
Graeme Prosperi-Porta1, Gregory Schnell2, Jillian Colbert2
1Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
The Canadian Journal of Cardiology
|February 25, 2018
Summary
Left atrial appendage occlusion devices offer stroke risk reduction in atrial fibrillation. A case highlights incomplete device healing leading to fatal clots, underscoring the need for optimal post-procedure care.
Area of Science:
- Cardiology
- Medical Devices
- Thrombosis
Background:
- Left atrial appendage occlusion (LAAO) devices are alternatives to anticoagulation for stroke prevention in nonvalvular atrial fibrillation (NVAF).
- Post-implantation thromboprophylaxis is recommended, but optimal regimens remain undefined.
Observation:
- A patient experienced multiple thromboembolic events following LAAO device implantation.
- A clinicopathologic examination revealed thrombus formation on an incompletely endothelialized WATCHMAN device.
Findings:
- Incomplete endothelialization of the WATCHMAN device was associated with adherent thrombus.
- The thrombus contributed to recurrent thromboembolic events, leading to a fatal outcome.
Implications:
- This case highlights critical uncertainties in the endothelialization process of LAAO devices.
- Further research is needed to establish optimal thromboprophylaxis strategies after LAAO implantation to prevent device-related thrombosis.
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