Related Experiment Video

Updated: Feb 14, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

84.6K

Multiple Thromboembolic Events from a Left Atrial Appendage Occlusion Device

Graeme Prosperi-Porta1, Gregory Schnell2, Jillian Colbert2

  • 1Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

The Canadian Journal of Cardiology
|February 25, 2018
PubMed

Insights

Left atrial appendage occlusion devices offer stroke risk reduction in atrial fibrillation. A case highlights incomplete device healing leading to fatal clots, underscoring the need for optimal post-procedure care.

Area of Science:

  • Cardiology
  • Medical Devices
  • Thrombosis

Background:

  • Left atrial appendage occlusion (LAAO) devices are alternatives to anticoagulation for stroke prevention in nonvalvular atrial fibrillation (NVAF).
  • Post-implantation thromboprophylaxis is recommended, but optimal regimens remain undefined.

Observation:

  • A patient experienced multiple thromboembolic events following LAAO device implantation.
  • A clinicopathologic examination revealed thrombus formation on an incompletely endothelialized WATCHMAN device.

Findings:

  • Incomplete endothelialization of the WATCHMAN device was associated with adherent thrombus.
  • The thrombus contributed to recurrent thromboembolic events, leading to a fatal outcome.

Implications:

  • This case highlights critical uncertainties in the endothelialization process of LAAO devices.
  • Further research is needed to establish optimal thromboprophylaxis strategies after LAAO implantation to prevent device-related thrombosis.

More Related Videos

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

34.2K
Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation07:28

Donor Posterior Atrial Flap Rotation for Left Atrial Cuff Reconstruction in Lung Transplantation

Published on: October 11, 2024

789

Related Concept Videos

Surface Appendages of Archaea01:23

Surface Appendages of Archaea

Archaeal surface appendages are highly specialized structures essential for environmental adaptation, encompassing roles in adhesion, biofilm formation, and motility. Among these appendages, pili and archaella stand out for their distinct morphologies and functionalities, enabling archaea to thrive in diverse and often extreme environments.Pili: Adhesion and Biofilm FormationPili are filamentous structures assembled from pilin protein subunits, primarily contributing to adhesion and biofilm...
691
Integration of Synaptic Events01:28

Integration of Synaptic Events

Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
4.2K
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
38.2K
Schwarzschild Radius and Event Horizon01:21

Schwarzschild Radius and Event Horizon

No object with a finite mass can travel faster than the speed of light in a vacuum. This fact has an interesting consequence in the domain of extremely high gravitational fields.
The minimum speed required to launch a projectile from the surface of an object to which it is gravitationally bound so that it eventually escapes the object’s gravitational field is called the escape velocity. The escape velocity is independent of the mass of the object. Merging the idea of escape...
2.8K
Multiple Regression01:25

Multiple Regression

Multiple regression assesses a linear relationship between one response or dependent variable and two or more independent variables. It has many practical applications.
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
4.0K
Multiple Voltage Sources01:25

Multiple Voltage Sources

Generally, a single battery is not enough to power some devices. In such cases, batteries can be combined in two ways: in series or in parallel.
In series, the positive terminal of one battery is connected to the negative terminal of another battery. Hence, the voltage of each battery is added to give the net voltage, which is increased because each battery boosts the electrons that enter it. The same current flows through each battery because they are connected in series.
Batteries are...
1.8K