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Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells
Published on: February 4, 2021
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[Radiation therapy in inflammatory breast cancer]
Pauline Jardel1, Zenab Alami2, Stéphane Vignot3
1Centre intégré universitaire du Saguenay-Lac-Saint-Jean, service de radio-oncologie, 305, rue Saint-Vallier, G7H5H6 Chicoutimi, Québec, Canada.
Bulletin Du Cancer
|February 25, 2018
Summary
Radiotherapy is crucial in multimodal treatment for inflammatory breast cancer, improving local control and survival rates. This analysis reviews its indications, techniques, and impact on patient outcomes.
Area of Science:
- Oncology
- Radiation Oncology
- Breast Cancer Research
Background:
- Inflammatory breast cancer (IBC) represents 1-5% of all breast cancers.
- IBC is characterized by a poor prognosis and high metastatic potential.
- Multimodal treatment is the standard approach for IBC.
Purpose of the Study:
- To evaluate the role of radiotherapy in inflammatory breast cancer.
- To analyze radiotherapy indications, techniques, and impact on local control and overall survival.
Main Methods:
- Systematic literature review of studies with over 40 patients irradiated for IBC since 1995.
- Analysis of treatment modalities, including chemotherapy, radiotherapy, and surgery.
Main Results:
- Adjuvant radiotherapy, following chemotherapy, improved 10-year local control (63-92%) and overall survival (51-64%).
- Without surgery, 10-year local control was 65% and overall survival was 38%.
- Radiotherapy details (dose, fractionation, target volumes, bolus) were analyzed, noting heterogeneity in concomitant radiochemotherapy studies.
Conclusions:
- Radiotherapy is an integral component of the multimodal strategy for IBC.
- Evaluating tumor response to radiotherapy is essential to maximize resectability.
- Optimized radiotherapy techniques contribute to improved patient outcomes in IBC.
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