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Updated: Feb 14, 2026

Measuring Diurnal Rhythms in Autophagic and Proteasomal Flux
Published on: September 17, 2019
The autophagic network and cancer
Marissa D Rybstein1, José Manuel Bravo-San Pedro2,3,4,5,6, Guido Kroemer2,3,4,5,6,7,8
1Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Abstract:
Mammalian cells harness autophagy to eliminate physiological byproducts of metabolism and cope with microenvironmental perturbations. Moreover, autophagy connects cellular adaptation with extracellular circuitries that impinge on immunity and metabolism. As it links transformed and non-transformed components of the tumour microenvironment, such an autophagic network is important for cancer initiation, progression and response to therapy. Here, we discuss the mechanisms whereby the autophagic network interfaces with multiple aspects of malignant disease.
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