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Histological-Based Stainings Using Free-Floating Tissue Sections
Published on: August 25, 2020
21.4K
Evaporation process in histological tissue sections for neutron autoradiography
Natalia M Espector1,2, Agustina Portu3,4, Gustavo A Santa Cruz3
1Facultad de Ingeniería, Universidad Favaloro, Buenos Aires, Argentina.
Radiation and Environmental Biophysics
|February 25, 2018
Summary
Accurate boron concentration measurement in tissue samples is crucial for Boron Neutron Capture Therapy (BNCT). This study models tissue sample evaporation to improve BNCT dosimetry and treatment planning.
Area of Science:
- Nuclear physics
- Medical physics
- Radiochemistry
Background:
- Nuclear track detectors (NTDs) analyze boron-10 (10B) distribution in tissue for Boron Neutron Capture Therapy (BNCT).
- Accurate 10B concentration is vital for BNCT dosimetry and treatment planning.
- Tissue sample drying during analysis alters mass and boron concentration, necessitating corrections.
Purpose of the Study:
- To investigate and model the mass variation of tissue samples during the drying process.
- To determine the most suitable mathematical model for describing tissue sample evaporation.
- To enhance the accuracy of boron concentration assessment in tissue samples for BNCT.
Main Methods:
- Cryosectioning of frozen tissue specimens.
- Recording mass evolution of tissue samples using a semimicro analytical scale.
- Applying and evaluating mathematical models (e.g., Page's model) to experimental evaporation data.
Main Results:
- Reproducible evaporation curves were obtained under recorded ambient conditions.
- Page's model demonstrated the best fit for the experimental evaporation data of BDIX rat tissue samples.
- Evaluation of correlation coefficients and parameter variability confirmed model suitability.
Conclusions:
- Mathematical modeling of evaporation is essential for accurate boron concentration determination in BNCT.
- Page's model provides a reliable method for correcting mass variations in tissue samples.
- This research contributes to more precise boron quantification using Neutron Autoradiography for improved BNCT outcomes.
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