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Updated: Feb 14, 2026

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
10:02

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

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Methylphenidate selectively modulates one sub-component of the no-go P3 in pediatric ADHD medication responders

Ida Emilia Aasen1, Geir Øgrim2, Juri Kropotov3

  • 1Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway; Department of Neuropsychology, Helgeland Hospital, Mosjøen, Norway.

Biological Psychology
|February 25, 2018
PubMed

Insights

Methylphenidate (MPH) treatment increased the amplitude of an early sub-component of the no-go P3 event-related potential (ERP) in children with ADHD. A later sub-component remained unaffected, suggesting distinct functional roles.

Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Cognitive Electrophysiology

Background:

  • Methylphenidate (MPH) is known to modulate the no-go P3 event-related potential (ERP) amplitude.
  • The no-go P3 can be decomposed into distinct sub-components using independent component analysis (ICA).
  • Understanding these sub-components is crucial for elucidating the neural mechanisms underlying ADHD and MPH effects.

Purpose of the Study:

  • To identify and characterize sub-components of the no-go P3 in children with Attention-Deficit/Hyperactivity Disorder (ADHD).
  • To investigate the modulatory effects of Methylphenidate (MPH) on the amplitudes of these identified no-go P3 sub-components.
  • To explore the functional correlates of distinct no-go P3 sub-components in the context of ADHD treatment.

Main Methods:

  • Electroencephalography (EEG) recordings were obtained from 57 children with ADHD twice: once on Methylphenidate (MPH) and once at baseline.
  • Participants were classified as medication responders following a four-week MPH trial.
  • Group independent component analysis (gICA) was employed to separate the no-go P3 into sub-components from a cued go/no-go task.

Main Results:

  • Two distinct no-go P3 sub-components were successfully identified in children with ADHD.
  • The amplitude of the early sub-component (IC P3no-goearly, mean latency 378 ms, central distribution) significantly increased during MPH treatment compared to baseline.
  • The late sub-component (IC P3no-golate, mean latency 428 ms, centro-frontal distribution) showed no significant modulation by MPH.

Conclusions:

  • The findings support the notion that the no-go P3 comprises at least two overlapping neural processes with differing functional roles.
  • Methylphenidate (MPH) selectively enhances the amplitude of an early, centrally distributed no-go P3 sub-component in children with ADHD.
  • These results contribute to a more nuanced understanding of the neurophysiological effects of MPH in ADHD, highlighting differential modulation of distinct ERP components.
Keywords:
ADHDCued go/no-goICAMPHNo-go P3

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