Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Force On A Current Loop In A Magnetic Field01:17

Force On A Current Loop In A Magnetic Field

4.3K
Magnetic forces on wires carrying current are most frequently applied in motors. A DC motor is a device that converts electrical energy into mechanical work. In motors, wire loops are enclosed in a magnetic field. When current flows through the loops, the magnetic field applies torque, which causes the shaft to rotate. The direction of the current is reversed once the loop's surface area is lined up with the magnetic field, causing a constant torque on the loop. During the process, commutators...
4.3K
Intermolecular Forces03:13

Intermolecular Forces

72.2K
Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen...
72.2K
Electromotive Force02:36

Electromotive Force

30.3K
Electricity is generated by either electrons or ions flowing through a solution or a conducting medium. This flow of electrons or specifically electrical charge is defined as an electric current. When electrons move through a wire, they generate an electric current. It can be recalled  that in a redox reaction, electrons are lost and gained. In the spontaneous redox reaction of zinc  with copper, when zinc is immersed in a copper ion solution, a transfer of electrons from one substance to...
30.3K
Intermolecular vs Intramolecular Forces03:00

Intermolecular vs Intramolecular Forces

97.9K
Intermolecular forces (IMF) are electrostatic attractions arising from charge-charge interactions between molecules. The strength of the intermolecular force is influenced by the distance of separation between molecules. The forces significantly affect the interactions in solids and liquids, where the molecules are close together. In gases, IMFs become important only under high-pressure conditions (due to the proximity of gas molecules). Intermolecular forces dictate the physical properties of...
97.9K
Intermolecular Forces in Solutions02:28

Intermolecular Forces in Solutions

40.0K
The formation of a solution is an example of a spontaneous process, a process that occurs under specified conditions without energy from some external source.
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Such a solution is called an ideal solution. A mixture of ideal gases (or gases such as helium and argon,...
40.0K
Force01:06

Force

32.2K
Forces affect every moment of our life. Our bodies are held to the Earth by force, and they are held together by the forces of charged particles. When we open a door, walk down a street, lift a fork, or touch a baby's face, we are applying force. Our body's atoms are held together by electrical forces, and the core of an atom, called the nucleus, is held together by the strongest force known to us—nuclear force.
The study of motion is called kinematics, but kinematics only...
32.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Machine-Learned Leftmost Hessian Eigenvectors for Robust Transition State Finding.

Journal of chemical theory and computation·2026
Same author

Energetics of Noncovalent Interactions of Protein-Ligand Complexes for Drug Discovery.

Journal of chemical information and modeling·2026
Same author

Sensing the acidity of hydrogen bond networks.

Physical chemistry chemical physics : PCCP·2026
Same author

SmileyLlama: modifying large language models for directed chemical space exploration.

Nature computational science·2026
Same author

Conformational Ensembles of the Disordered 4E-BP2:eIF4E Complex Restrained by smFRET Experiments.

bioRxiv : the preprint server for biology·2026
Same author

LinkLlama: Enabling Large Language Model for Chemically Reasonable Linker Design.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Feb 14, 2026

Simulation of Human-induced Vibrations Based on the Characterized In-field Pedestrian Behavior
10:52

Simulation of Human-induced Vibrations Based on the Characterized In-field Pedestrian Behavior

Published on: April 13, 2016

9.2K

New developments in force fields for biomolecular simulations.

Paul S Nerenberg1, Teresa Head-Gordon2

  • 1Departments of Physics & Astronomy and Biological Sciences, California State University, Los Angeles, CA 90032, United States.

Current Opinion in Structural Biology
|February 25, 2018
PubMed
Summary
This summary is machine-generated.

Recent advancements in biomolecular force fields, driven by large datasets and computing power, enhance molecular simulation accuracy for proteins, nucleic acids, and small molecules. This review covers new methods and future directions in force field development.

More Related Videos

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology
09:39

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology

Published on: March 31, 2022

3.7K
Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

13.5K

Related Experiment Videos

Last Updated: Feb 14, 2026

Simulation of Human-induced Vibrations Based on the Characterized In-field Pedestrian Behavior
10:52

Simulation of Human-induced Vibrations Based on the Characterized In-field Pedestrian Behavior

Published on: April 13, 2016

9.2K
Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology
09:39

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology

Published on: March 31, 2022

3.7K
Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

13.5K

Area of Science:

  • Computational chemistry and biophysics.
  • Molecular modeling and simulation.
  • Drug discovery and development.

Background:

  • Biomolecular force field development has advanced molecular simulation predictive power for four decades.
  • Recent progress is fueled by large experimental datasets and high-performance computing.
  • Accurate force fields are crucial for understanding complex biophysical problems.

Purpose of the Study:

  • To review recent developments in all-atom protein, nucleic acid, and small molecule force fields.
  • To highlight advancements in parameterization methods and nonbonded interaction representations.
  • To outline future directions and applications in force field development.

Main Methods:

  • Review of recent literature on biomolecular force fields.
  • Analysis of parameterization techniques.
  • Evaluation of nonbonded interaction models.

Main Results:

  • Summary of progress in protein, nucleic acid, and small molecule force fields.
  • Identification of key improvements in parameterization and nonbonded interactions.
  • Discussion of emerging trends and challenges.

Conclusions:

  • Continued development of biomolecular force fields is essential for tackling complex biophysical challenges.
  • Integration of large datasets and computational power accelerates progress.
  • Future research will focus on novel methods and grand challenge applications.