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Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

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Published on: December 9, 2010

Engineered nanomaterial applications in perinatal therapeutics.

S B Fournier¹, J N D'Errico², P A Stapleton³

¹Environmental and Occupational Health Sciences Institute, 170 Frelinghuysen Rd., Piscataway, NJ 08854, USA.

Pharmacological Research

|February 26, 2018

Summary

Engineered nanomaterials (ENM) show promise for targeted therapies in perinatal medicine. This review examines their properties, testing, and safety for maternal-fetal health during gestation.

Keywords:

Engineered nanomaterials Maternal and fetal medicine Nanotoxicology Perinatal Placenta

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Biofunctionalization of Magnetic Nanomaterials

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Area of Science:

Biomedical Engineering
Perinatal Medicine
Nanotoxicology

Background:

Engineered nanomaterials (ENM) are increasingly used in biomedical applications.
Prenatal treatments are often avoided due to potential adverse effects on the developing fetus.
The placenta plays a critical role in maternal-fetal exchange and hormone production.

Purpose of the Study:

To review the potential applications of ENM in perinatal medicine.
To discuss the physiochemical properties of ENM relevant to therapeutic use.
To identify maternal, fetal, and offspring concerns related to ENM exposure during gestation.

Main Methods:

Literature review of ENM applications in perinatal medicine.
Analysis of ENM physiochemical properties for targeted delivery.
Evaluation of current ENM testing methodologies in perinatal contexts.

Main Results:

ENM offer potential for individualized and tissue-targeted therapies.
Placental function can be perturbed by ENM, affecting nutrient transfer and hormone production.
Specific ENM properties influence their interaction with maternal-fetal systems.

Conclusions:

ENM hold promise for novel perinatal therapeutics.
Thorough evaluation of ENM safety and efficacy is crucial for clinical translation.
Understanding ENM interactions is vital for mitigating risks in pregnant patients and offspring.