Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

4.4K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.4K
Cellular Differentiation00:57

Cellular Differentiation

5.6K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
5.6K
Cellular Respiration01:18

Cellular Respiration

2.1K
Cellular respiration is a crucial metabolic process through which cells obtain energy from organic substances, mainly glucose, to produce adenosine triphosphate (ATP). This process includes the oxidation of substrates and the transfer of electrons to a separate electron acceptor, facilitating ATP synthesis through a sequence of biochemical reactions.Glycolysis: The Initial StepGlycolysis is the first stage of cellular respiration, occurring in the cytoplasm of both prokaryotic and eukaryotic...
2.1K
Introduction to Cellular Respiration01:22

Introduction to Cellular Respiration

190.3K
Organisms harvest energy from food, but this energy cannot be directly used by cells. Cells convert the energy stored in nutrients into a more usable form: adenosine triphosphate (ATP).
ATP stores energy in chemical bonds that can be quickly released when needed. Cells produce energy in the form of ATP through the process of cellular respiration. Although much of the energy from cellular respiration is released as heat, some of it is used to make ATP.
During cellular respiration, several...
190.3K
Cellular Membranes and Drug Transport01:24

Cellular Membranes and Drug Transport

1.6K
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
1.6K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

16.9K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
16.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA.

Developmental cell·2026
Same author

SenFlag gene signature identifies senescent cells in mouse and human tissues through a conserved core transcriptional program.

The EMBO journal·2026
Same author

Effects of nutritional interventions on biomarkers of cellular senescence in humans: A systematic review.

Ageing research reviews·2026
Same author

Response to: Limitations of the p16-3MR mouse model for detecting and eliminating senescent cells.

EMBO reports·2026
Same author

Public health in the age of longevity interventions: from prevention to system-wide resilience.

Aging·2026
Same author

The Role of CaV3.2 T-type calcium channels in normal hearing and acquired hearing loss.

Cell calcium·2026

Related Experiment Video

Updated: Feb 14, 2026

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

35.2K

Hallmarks of Cellular Senescence.

Alejandra Hernandez-Segura1, Jamil Nehme1, Marco Demaria1

  • 1European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Trends in Cell Biology
|February 26, 2018
PubMed
Summary

Cellular senescence, a cell cycle arrest, aids development but harms aging tissues. Identifying and targeting senescent cells is crucial for aging research, despite current marker limitations.

More Related Videos

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

18.1K
A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.6K

Related Experiment Videos

Last Updated: Feb 14, 2026

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

35.2K
Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

18.1K
A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.6K

Area of Science:

  • Gerontology
  • Cell Biology
  • Molecular Biology

Background:

  • Cellular senescence is a permanent cell cycle arrest with dual roles in development and aging.
  • Senescence contributes to age-related decline, inflammation, and cancer.
  • Current methods for identifying senescent cells are limited by marker nonspecificity and diverse senescence programs.

Purpose of the Study:

  • To describe molecular regulators of senescence phenotypes.
  • To explain how these regulators identify senescent cells in vitro and in vivo.
  • To highlight the therapeutic potential of targeting senescence regulation.

Main Methods:

  • Review of molecular regulators of senescence phenotypes.
  • Analysis of methods for identifying senescent cells.
  • Discussion of therapeutic target development based on senescence regulation.

Main Results:

  • Senescence involves complex molecular regulation.
  • Specific regulators can be used to identify senescent cells.
  • Understanding these regulators is key for therapeutic interventions.

Conclusions:

  • Molecular regulators are essential for understanding and targeting cellular senescence.
  • Improved identification of senescent cells can be achieved through understanding their molecular basis.
  • Targeting senescence pathways offers potential therapeutic strategies for age-related diseases.